Analysis on drug resistance and risk factors of 522 cases of nosocomial infection with ESBLs Escherichia coli

CHEN Dingding; DU Pengfei

doi:10.13919/j.issn.2095-6274.2015.07.009

Abstract：Objective To understand the drug resistance and risk factors of nosocomial infections with ESBLs Escherichia coli, in order to provide basis for preventing bacterial infection, and clinical medication.Methods ESBLs Escherichia coli infection cases of the second hospital affiliated to Anhui medical university in 2012 were surveyed, and retrospectively analyzed its drug resistance and infection risk factors.Results There were total 522 cases of ESBLs Escherichia coli infection in our hospital in 2012, and nearly half came from urine (44.44%), 22.99% of that from sputum. ESBLs Escherichia coli resistance level to cefazolin, ceftriaxone, cefotaxime were as high as 100.00%, 99.04% and 98.14%, respectively. Resistance rate for ceftriaxone and cefoxitin were 82.18% and 19.92%, respectively. And bacteria resistance to imipenem and meropenem was not found. Risk factors for ESBLs Escherichia coli infection include pre-existing diseases, elder, invasive operation, variety use of antibacterial drugs for a long time, and long hospitalization days, while gender was not.Conclusions ESBLs Escherichia coli resistance level to cefazolin, ceftriaxone, cefotaxime and ceftazidime were high, and that to cefoxitin was low. It was sensitive to imipenem and meropenem. Interventions should be applied to hospitalized patients with underlying disease existing, elder, invasive operation, using a variety of antibacterial drugs with a long time, and long hospitalization days to prevent bacterial infection.