The Predictive Value of Platelet-to-Lymphocyte Ratio for PICC-Associated Upper Extremity Venous Thrombosis in Lung Cancer Patients Under DSA Guidance
ZHAO Weijia
ZHAO Jing
XIAO Yuelan
LI Wenzhen
KONG Nanfang
FANG Xinjian
YANG Liang
Abstract：Objective To explore the predictive value of the platelet-to-lymphocyte ratio(PLR)for peripherally inserted central catheter-associated upper extremity venous thrombosis(PICC-UEVT)in lung cancer patients under digital subtraction angiography(DSA)guidance.Methods A total of 160 lung cancer patients treated at the Affiliated Gaochun Hospital of Jiangsu University from January 2022 to February 2025 were selected.According to the occurrence of PICC-UEVT,the patients were divided into a thrombosis group(n=36)and a non-thrombosis group(n=124).The receiver operating characteristic curve was constructed to evaluate the predictive value of PLR for PICC-UEVT in lung cancer patients under DSA guidance.Multivariate logistic regression analysis was used to analyze the influencing factors for PICC-UEVT in these patients.Results The platelet count(PLT)and PLR in the thrombosis group were significantly higher than those in the non-thrombosis group,while the lymphocyte count(LYM)was significantly lower(P<0.05).The area under the curve(95%CI)of PLR for predicting PICC-UEVT was 0.910(0.870-0.953),which was significantly higher than that of PLT alone 0.847(0.796-0.895)and LYM count alone 0.753(0.702-0.804)(Z=8.328,9.741,P<0.001).The age,body mass index,and the proportions of patients with diabetes,pre-catheterization D-dimer≥0.5 mg/L,and activities of daily living(ADL)score<65 were all significantly higher in the thrombosis group than in the non-thrombosis group(P<0.05).Multivariate analysis showed that diabetes(OR=2.392,95%CI:1.417-4.036),pre-catheterization D-dimer≥0.5 mg/L(OR=2.818,95%CI:1.408-5.640),ADL score<65(OR=2.356,95%CI:1.421-3.907),and PLR≥203.82(OR=2.779,95%CI:1.458-5.295)were independent risk factors for PICC-UEVT in lung cancer patients under DSA guidance(P<0.05).Conclusion Elevated PLR is closely related to PICC-UEVT in lung cancer patients under DSA guidance and demonstrates good predictive efficacy.
Keywords：platelet-to-lymphocyte ratiolung cancerdigital subtraction angiographyperipherally inserted central catheterupper extremity venous thrombosis
Publication Date：2026-03-20
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：5( 436-440 )