Research Progress on Traditional Chinese Medicine Monomers Reversing Cisplatin Resistance in Cervical Cancer by Modulating Autophagy
WANG Dan
YANG Wan
WU Yicai
ZOU Yin
ZHOU Zhihua
Abstract：Cervical cancer is a common malignancy that seriously threatens women's health.Cisplatin-based chemotherapy is an important treatment for cervical cancer,but the development of drug resistance often leads to treatment failure.Autophagy plays a dual role in tumor development,and its abnormal activation is a key mechanism mediating cisplatin resistance in cervical cancer.Traditional Chinese medicine monomers offer advantages such as multi-target effects,low toxicity,and synergistic benefits,demonstrating great potential in reversing tumor drug resistance.This article aims to review recent advances in three categories of traditional Chinese medicine monomers—flavonoids,alkaloids,and terpenoids—in reversing cisplatin resistance in cervical cancer by regulating key signaling pathways such as PI3K/Akt/mTOR,AMPK,and MAPK,and intervening in autophagy processes.The article will focus on the mechanisms of action of each type of monomer,with the goal of providing a theoretical reference for understanding the molecular mechanisms of traditional Chinese medicine monomers in reversing drug resistance and developing new clinical combination drug strategies.
Keywords：traditional Chinese medicine monomerautophagycervical cancercisplatin resistanceflavonoidsalkaloidsterpenoidsdrug resistance
Publication Date：2026-02-20
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：6( 355-360 )