The Degree of Cancer-Related Fatigue and Its Relationship with Perceived Control and Hope Level in Patients with Colorectal Cancer after Chemoradiotherapy

JIANG Shanshan; ZHONG Mengshi; XU Ling; GAO Jie; RAN Caiping; YU Yangyang; LI Chun

doi:10.3639/j.issn.2095-3097.2026.02.014

Abstract：Objective To explore the degree of cancer-related fatigue in patients with colorectal cancer after chemoradiotherapy and its relationship with perceived control and hope level.Methods A total of 152 patients with colorectal cancer after chemoradiotherapy admitted to Huai'an First Hospital Affiliated to Nanjing Medical University from June 2022 to October 2024 were enrolled.The cancer fatigue scale(CFS),cancer experience and efficacy scale(CEES),and Herth hope index(HHI)were used to assess cancer-related fatigue,perceived control,and hope level.Pearson correlation analysis was used to analyze the correlations among the scores of each scale.Multiple linear regression was used to identify independent factors associated with cancer-related fatigue.Results In patients with colorectal cancer after chemoradiotherapy,the CFS score was(36.88±5.85).The scores for the cancer experience and control efficacy subscales of the CEES were(49.79±8.42)and(36.42±4.55),respectively.The HHI score was(26.26±3.66).The CFS score was positively correlated with the cancer experience score of the CEES(P<0.05),while both were negatively correlated with the control efficacy score of the CEES and the HHI score(P<0.05).Patients who were aged≥55 years,had a high school education or below,lived alone,had TNM stage Ⅳ disease,or experienced grade 3-4 adverse reactions had significantly higher CFS scores than their counterparts(aged<55 years,college education or above,not living alone,TNM stage Ⅲ,grade 0-2 adverse reactions)(P<0.05).Multiple linear regression analysis showed that age,educational level,living status,TNM stage,adverse reactions,and the scores of cancer experience,control efficacy,and hope level were independent factors influencing the degree of cancer-related fatigue in patients after chemoradiotherapy(P<0.05),explaining 64.40%of the total variance.Conclusion The degree of cancer-related fatigue is relatively high in patients with colorectal cancer after chemoradiotherapy.It is significantly correlated with patients'cancer experience,control efficacy,and hope level,and is influenced by multiple factors such as age and educational level.Targeted clinical interventions should be implemented to improve patients'cancer experience,enhance their control efficacy and hope level,aiming to alleviate cancer-related fatigue.