Correlation Between Serum CCL2 and CXCL8 Levels and In-Stent Restenosis after PCI in Patients with Coronary Heart Disease
SUN Ning
GUAN Xin
Abstract：Objective To investigate the correlation between serum levels of C-C motif chemokine ligand 2(CCL2)and C-X-C motif chemokine ligand 8(CXCL8)and in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD).Methods A total of 202 CHD patients who were admitted to Baoji People's Hospital and underwent PCI from July 2019 to July 2020 were enrolled.Based on the occurrence of ISR within 18 months after PCI,the patients were divided into an ISR group(32 cases)and a non-ISR group(170 cases).Clinical data were collected,and serum levels of CCL2 and CXCL8 were measured.Multivariate logistic regression analysis was used to identify independent influencing factors for ISR after PCI in CHD patients.Relative risk analysis was conducted to determine the impact of high versus low levels of CCL2 and CXCL8 on ISR.Receiver operating characteristic(ROC)curves were plotted to analyze the predictive value of CCL2 and CXCL8 levels for ISR.Results The proportion of diabetes,low-density lipoprotein cholesterol(LDL-C)levels,and serum levels of CCL2 and CXCL8 were significantly higher in the ISR group than in the non-ISR group(P<0.05).Multivariate logistic regression analysis showed that elevated LDL-C(OR=2.305,95%CI:1.202-4.419),elevated CCL2(OR=2.643,95%CI:1.114-6.273),and elevated CXCL8(OR=2.921,95%CI:1.236-6.906)were risk factors for ISR after PCI in CHD patients(P<0.05).Relative risk analysis showed that the risk of ISR in patients with high serum levels of CCL2 and CXCL8 was 2.136 times and 2.614 times higher,respectively,than that in patients with low levels.ROC curve analysis revealed that the area under the curve(AUC)for predicting postoperative ISR in CHD patients was 0.739 for CCL2 and 0.682 for CXCL8.The combined prediction of both markers yielded an AUC of 0.820,which was higher than that of either single indicator(Zcombined vs CCL2=2.031,P=0.042;Zcombined vs CXCL8=2.786,P=0.005).Conclusion Serum levels of CCL2 and CXCL8 were elevated in CHD patients with ISR.Both are independent risk factors for ISR after PCI in CHD patients and have good predictive value for ISR after PCI.
Keywords：coronary heart diseaseC-C motif chemokine ligand 2C-X-C motif chemokine ligand 8coronary in-stent restenosis
Publication Date：2026-02-20
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：5( 181-185 )