Effect of Esketamine on Postoperative Sleep Quality in Patients Undergoing Thoracoscopic Surgery
SHEN Shuai
CHEN Yu
LIU Yong
TAN Lei
NI Xiaolei
SU Xiaohu
Abstract：Objective To observe the effect of esketamine on postoperative sleep quality in patients undergoing thoracoscopic surgery.Methods From January 2024 to June 2025,100 patients undergoing thoracoscopic surgery at Suqian First People's Hospital Affiliated to Nanjing Medical University were selected and divided into group A(conventional general anesthesia+postoperative analgesia)and group B(conventional general anesthesia+esketamine for postoperative analgesia)according to the random number table method,with 50 patients in each group.The analgesic and sedative effects,sleep quality and insomnia severity,inflammatory markers[procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin 6(IL-6)],stress indicators(epinephrine,norepinephrine,and fasting blood glucose),and adverse reactions were compared between the two groups.Results At 12 h,24 h,and 48 h after surgery,the Visual Analogue Scale(VAS)scores of both groups gradually decreased over time(P<0.05),while the Ramsay sedation scores gradually increased over time(P<0.05).The VAS scores of group B were lower than those of group A at the same time points(P<0.05),and the Ramsay scores were higher than those of group A(P<0.05).At 48 h after surgery,the Pittsburgh Sleep Quality Index(PSQI)scores decreased(P<0.05)and the Insomnia Severity Index(ISI)scores increased in both groups(P<0.05),with group B showing lower PSQI and ISI scores than group A(P<0.05).At 48 h after surgery,the levels of PCT,hs-CRP,TNF-α,IL-6,epinephrine,norepinephrine,and fasting blood glucose increased in both groups(P<0.05),but were lower in group B than in group A(P<0.05).The incidence of adverse reactions in group A(18.00%)was comparable to that in group B(22.00%),with no statistically significant difference(P>0.05).Conclusion The application of esketamine in thoracoscopic surgery can produce significant analgesic and sedative effects,improve patients'sleep quality,reduce postoperative inflammatory and stress responses,and has a high safety profile.
Keywords：thoracoscopyesketamineanesthesia and analgesiasleep quality
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：6( 154-159 )