Relationship Between IL-6,HLA-G,Tim-3 and Clinicopathological Indicators and Prognosis in Patients with Acute Myeloid Leukemia
LEI Liang
HOU Ruihong
JI Xia
Abstract：Objective To investigate the relationship between interleukin-6(IL-6),human leukocyte antigen G(HLA-G),T-cell immunoglobulin and mucin domain 3(Tim-3)and clinicopathological indicators and prognosis in patients with acute myeloid leukemia(AML).Methods A total of 113 AML patients admitted to Linfen People's Hospital from March 2020 to November 2023 were selected as the study group,and 80 normal individuals during the same period were selected as the control group.Serum levels of IL-6,HLA-G,and Tim-3 were detected and compared between the two groups,and the relationship between the expression levels of IL-6,HLA-G,Tim-3 and clinicopathological indicators in AML patients was analyzed.According to the one-year prognosis,AML patients were divided into a survival group(85 cases)and a death group(28 cases),and serum levels of IL-6,HLA-G,and Tim-3 were compared between the two groups.Receiver operating characteristic(ROC)curves were plotted to analyze the predictive value of serum IL-6,HLA-G,and Tim-3 levels for the prognosis of AML patients.Results Serum levels of IL-6,HLA-G,and Tim-3 in the AML patient group were significantly higher than those in the control group(P<0.05).Serum levels of IL-6,HLA-G,and Tim-3 in AML patients were related to peripheral blood white blood cell count and European Leukemia Net(ELN)risk stratification(P<0.05).Serum levels of IL-6,HLA-G,and Tim-3 in the death group were higher than those in the survival group(P<0.05).The areas under the curve(AUC)of serum IL-6,HLA-G,and Tim-3 for predicting the prognosis of AML patients were 0.829,0.840,and 0.787,respectively.The AUC for the combination of the three markers was 0.948,which was better than that of each individual predictor(Z combination vs IL-6=2.497,Z combination vs HLA-G=2.957,Z combination vs Tim-3=3.207,all P<0.05).Conclusion Serum levels of IL-6,HLA-G,and Tim-3 are significantly elevated in AML patients,and their expression levels are related to peripheral blood white blood cell count and ELN risk stratification.The combination of the three markers may assist in predicting the prognosis of AML patients.
Keywords：acute myeloid leukemiainterleukin-6human leukocyte antigen-GT-cell immunoglobulin and mucin domain-3pathologyreceiver operating characteristic curve
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：5( 100-104 )