Relationship Between Amplitude-Integrated Electroencephalogram Signals,Ferritin Levels,and Vascular Cognitive Impairment in Patients with Ischemic Cerebral Small Vessel Disease
ZU Yanying
LAN Xifa
TAN Limei
YANG Shuai
LIU Shisong
DU Hailong
Abstract：Objective To investigate the relationship of amplitude-integrated electroencephalogram(aEEG)signals and ferritin levels with vascular cognitive impairment in patients with ischemic cerebral small vessel disease(iCSVD).Methods A total of 126 patients with iCSVD treated in Qinhuangdao First Hospital from June 2023 to December 2024 were retrospectively selected and divided into a vascular cognitive impairment group(39 cases)and a non-impaired group(87 cases)according to the presence of vascular cognitive impairment.aEEG signals(continuity of background activity,sleep cycle,upper and lower boundary voltages),serum ferritin levels,and clinical data were compared between the two groups.Multivariate Logistic regression was used to analyze independent influencing factors for vascular cognitive impairment in iCSVD patients.Results Compared with the non-impaired group,the vascular cognitive impairment group showed higher proportions of abnormal background activity continuity and abnormal sleep cycle,lower upper and lower boundary voltage levels,higher serum ferritin level,higher homocysteine level,a higher proportion of high cerebrovascular disease load,and a higher white matter lesion severity score,with statistically significant differences(P<0.05).Multivariate Logistic regression analysis showed that aEEG background activity continuity(OR=1.264,95%CI:1.017-1.571),sleep cycle(OR=1.420,95%CI:1.092-1.847),serum ferritin level(OR=1.028,95%CI:1.008-1.049),and high cerebrovascular disease load(OR=1.441,95%CI:1.101-1.884)were associated with vascular cognitive impairment in iCSVD patients(P<0.05).Conclusion aEEG background activity continuity,sleep cycle,serum ferritin level,and high cerebrovascular disease load are associated with vascular cognitive impairment in patients with iCSVD.
Keywords：ischemic cerebral small vessel diseaseamplitude-integrated electroencephalogram signalferritinvascular cognitive impairment
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：5( 84-88 )