Analysis of the Expression and Prognostic Predictive Value of SATB2,MSH2 and MSH6 in Colorectal Cancer Tissues
CHEN Chaoqian
ZHAO Zongxian
HU Zongju
YAO Yuan
XU Shun
Abstract：Objective To investigate the expression of special AT-rich sequence-binding protein 2(SATB2)and mismatch repair proteins[MutS homolog 2(MSH2),MSH6]in colorectal cancer tissues,and to analyze the predictive value of single and combined detection of the three for prognosis.Method A total of 124 colorectal cancer patients admitted to Fuyang People's Hospital from January 2022 to November 2024 were selected as research subjects.The expression of SATB2,MSH2,and MSH6 in colorectal cancer tissues and paracancerous tissues was compared,and the differences in their expression among patients with different pathological characteristics and different prognoses were analyzed.Spearman correlation analysis was used to analyze the correlation between the expression of SATB2,MSH2,MSH6 and colorectal cancer prognosis.Receiver operating characteristic(ROC)curves were created to analyze the predictive value of SATB2,MSH2,and MSH6 for colorectal cancer prognosis.Results The positive expression rate of SATB2 in colorectal cancer tissues was 54.84%,significantly lower than the 90.32%in paracancerous tissues(P<0.05).The loss rates of MSH2 and MSH6 expression in colorectal cancer tissues were 9.68%and 7.26%,respectively,significantly higher than the 2.42%and 0.81%in paracancerous tissues(P<0.05).The positive expression rate of SATB2 in patients with TNM stage Ⅰ-Ⅱ colorectal cancer was significantly higher than in patients with stage Ⅲ-Ⅳ(P<0.05).The positive expression rate of SATB2 in the poor prognosis group was significantly lower than in the good prognosis group(P<0.05),while the loss rates of MSH2 and MSH6 were significantly higher than in the good prognosis group(P<0.05).Spearman rank correlation analysis showed that SATB2 positive expression was inversely correlated with poor prognosis(r=-0.246,P=0.006),while MSH2 and MSH6 loss were positively correlated with poor prognosis(rMSH2=0.476,PMSH2<0.001;rMSH6=0.369,PMSH6<0.001).ROC curve analysis showed that the combined detection of SATB2,MSH2,and MSH6 had a sensitivity,specificity,and area under the curve(AUC)of 89.29%,64.58%,and 0.852,respectively,significantly better than single detection of the three(ZSATB2=3.517,PSATB2<0.001;ZMSH2=3.937,PMSH2<0.001;ZMSH6=5.206,PMSH6<0.001).Conclusion SATB2 shows low expression in colorectal cancer tissues,while MSH2 and MSH6 have high loss rates in colorectal cancer tissues.All three are significantly correlated with the prognosis of colorectal cancer patients and can be used for predicting colorectal cancer prognosis.
Keywords：specific AT-rich sequence-binding protein 2mismatch repair proteincolorectal cancerprognosis
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：5( 63-67 )