Predictive Value of Combined Detection of Homocysteine and Thrombelastography for Recurrent Preeclampsia
WANG Juanjuan
JIN Ruilin
WANG Min
ZHANG Ying
DING Xianghui
SUN Mengxiong
Abstract：Objective To analyze the predictive value of homocysteine(Hcy)combined with thrombelastogram(TEG)for recurrent preeclampsia(PE).Methods A total of 60 patients with recurrent PE(recurrent PE group),68 patients with first-onset PE(first-onset PE group),and 80 healthy pregnant women(normal group)admitted to the 81st Group Army Hospital of the People's Liberation Army from January 2022 to December 2024 were enrolled.Hcy levels and TEG parameters[coagulation index(CI),maximum amplitude(MA),α-angle(Angle),reaction time(R),coagulation time(K)]were compared among the three groups at 11-15 weeks,16-20 weeks,and 24-28 weeks of gestation.All subjects were followed up until after delivery.According to perinatal outcomes,they were divided into a good perinatal outcome group(n=164)and a poor perinatal outcome group(n=44).Hcy levels and TEG parameters at different gestational periods were compared between the two groups.Receiver operating characteristic(ROC)curves were plotted to analyze the predictive value of Hcy combined with TEG fitting values at 11-15 weeks,16-20 weeks,and 24-28 weeks of gestation for recurrent PE and poor perinatal outcomes.Results Compared with the normal group,the first-onset PE group and the recurrent PE group had higher Hcy,CI,MA,and Angle(P<0.05),and lower R and K(P<0.05)at 11-15 weeks,16-20 weeks,and 24-28 weeks of gestation.The recurrent PE group showed higher Hcy,CI,MA,and Angle(P<0.05),and lower R and K(P<0.05)than the first-onset PE group.ROC curve analysis showed that the areas under the curve of Hcy combined with TEG fitting values at 11-15 weeks,16-20 weeks,and 24-28 weeks of gestation for predicting recurrent PE were 0.942,0.979,and 0.941,respectively.Compared with the good perinatal outcome group,the poor perinatal outcome group had higher Hcy,CI,MA,and Angle(P<0.05),and lower R and K(P<0.05)at 11-15 weeks,16-20 weeks,and 24-28 weeks of gestation.ROC curve analysis showed that the areas under the curve of Hcy combined with TEG fitting values at 11-15 weeks,16-20 weeks,and 24-28 weeks of gestation for predicting poor perinatal outcomes were 0.856,0.944,and 0.959,respectively.Conclusion Combined detection of Hcy and TEG at 16-20 weeks of gestation can effectively predict the occurrence of recurrent PE,while combined detection at 24-28 weeks of gestation has the highest value for predicting adverse perinatal outcomes caused by recurrent PE.
Keywords：recurrent preeclampsiafirst-onset preeclampsiahomocysteinethrombelastography
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：6( 57-62 )