Predictive Value of Peripheral Blood Anti-Müllerian Hormone and Thyroid Specific Antibodies for Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome
LAN Bo
MING Lumin
ZHANG Ruiling
WANG Yan
LAN Ruilun
LIU Jin
Abstract：Objective To explore the predictive value of peripheral blood anti-Müllerian hormone(AMH)and thyroid-specific antibody levels on pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods A total of 120 patients with PCOS admitted to Jiangjin District Maternal and Child Health Hospital of Chongqing from January 2022 to January 2024 were included for retrospective analysis.All patients underwent detection of peripheral blood AMH,thyroid-stimulating hormone(TSH),and thyroid-specific antibodies[thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)].According to pregnancy outcomes,patients were divided into a pregnancy group(73 cases)and a non-pregnancy group(47 cases).The levels of peripheral blood AMH,TSH,TPOAb,and TGAb were compared between the two groups.The pregnant patients were followed up and further divided into a good pregnancy outcome group(44 cases)and a poor pregnancy outcome group(29 cases)based on their pregnancy outcomes.The predictive value of peripheral blood AMH,TSH,and thyroid-specific antibody levels on pregnancy outcomes and their influence on pregnancy outcomes were analyzed.Results The levels of AMH,TPOAb,and TGAb in the non-pregnancy group were higher than those in the pregnancy group(P<0.05).The levels of AMH,TPOAb,and TGAb in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).The area under the curve(AUC)of the combination of AMH,TPOAb,and TGAb for predicting pregnancy outcomes in PCOS patients was greater than that of each indicator alone(P<0.05).The proportions of patients with pre-pregnancy BMI≥25.00 kg/m²,gestational hypertension,gestational diabetes mellitus,AMH≥7.07 ng/mL,TPOAb≥70.89 IU/mL,and TGAb≥58.88 IU/mL in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).Gestational hypertension,gestational diabetes mellitus,AMH≥7.07 ng/mL,TPOAb≥70.89 IU/mL,and TGAb≥58.88 IU/mL were identified as independent influencing factors for pregnancy outcomes in PCOS patients(P<0.05).Conclusion Abnormally elevated levels of peripheral blood AMH,TPOAb,and TGAb are independent influencing factors for poor pregnancy outcomes in PCOS patients,and the combined detection of these indicators has good predictive value for pregnancy outcomes.
Keywords：polycystic ovary syndromeAnti-Müllerian Hormonethyroid specific antibodiespregnancy outcomespredictive value
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：4( 11-14 )