Expression Levels of Serum TLR9 and GDF15 in Patients with Sepsis and Their Relationship with the Occurrence of Acute Kidney Injury
XING Binyu
SHEN Cunyi
LIN Ting
TAN Wenjun
Abstract：Objective To investigate the relationship between the levels of Toll-like receptor 9(TLR9)and growth differentiation factor 15(GDF15)and the occurrence of acute kidney injury(AKI)in patients with sepsis.Methods A total of 106 patients with sepsis admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January 2020 to June 2024 were retrospectively selected as the control group,and 160 patients with sepsis-associated AKI during the same period were selected as the study group.The clinical data and expression levels of TLR9 and GDF15 were compared between the two groups.Spearman correlation analysis was used to explore the correlation between TLR9 and GDF15 expression levels and the occurrence of AKI in sepsis patients.Receiver operating characteristic(ROC)curve analysis was applied to evaluate the predictive value of TLR9 and GDF15 expression levels for AKI.Results The levels of respiratory rate,heart rate,glucose,creatinine,lactate,along with the proportion of infection originating from an intra-abdominal source,in the study group were higher than those in the control group,while the levels of oxygen saturation,albumin,hemoglobin,platelet count,and mean arterial pressure(MAP)were lower(P<0.05).The expression levels of TLR9 and GDF15 in the study group were higher than those in the control group(P<0.05).Spearman correlation analysis showed that the expression levels of TLR9 and GDF15 were positively correlated with the occurrence of AKI(r=0.587,0.621,both P<0.05).lactate(OR=2.309,95%CI:1.184-4.506),MAP(OR=2.155,95%CI:1.066-4.356),creatinine(OR=2.077,95%CI:1.014-4.256),TLR9(OR=2.606,95%CI:1.471-4.620),and GDF15(OR=2.492,95%CI:1.437-4.322)were identified as independent risk factors for AKI in sepsis patients(P<0.05).The area under the curve of TLR9,GDF15,and their combination for predicting sepsis-associated AKI were 0.812,0.759,and 0.813,respectively.Conclusion The expression levels of TLR9 and GDF15 are closely associated with the occurrence of sepsis-associated AKI and may serve as predictive indicators for sepsis-associated AKI.
Keywords：sepsisToll-like receptor 9growth differentiation factor 15acute kidney injury
Publication Date：2026-01-20
Online Publishing Date：2026-01-24(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )