Effect of Glucocorticoids on Lymphocytes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
HAN Xiaoping
LU Jiayan
ZHANG Meiting
GUO Qixia
LU Wei
Abstract：Objective To explore the effect of glucocorticoids on lymphocytes in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 60 AECOPD patients admitted to Rugao Branch Hospital of Nantong University from January 2023 to March 2024 were selected and divided into a control group(n=30,receiving conventional treatment)and an experimental group(n=30,receiving conventional treatment plus glucocorticoids)according to the treatment regimen.The following parameters were compared between the two groups before and after treatment:T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),B lymphocytes(CD19+cells),and NK cell levels;pulmonary function[forced expiratory volume in one second as a percentage of predicted value(FEV1%),ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)];arterial partial pressure of carbon dioxide,arterial partial pressure of oxygen;inflammatory factor levels(C-reactive protein,interleukin-6,tumor necrosis factor-α);and the incidence of adverse reactions.Results After treatment,the experimental group showed lower levels of CD4+,CD4+/CD8+,CD19+cells,and NK cells compared to the control group(P<0.05).The experimental group also had higher FEV1%and FEV1/FVC values after treatment than the control group(P<0.05).Compared with the control group,the experimental group exhibited lower arterial partial pressure of carbon dioxide,lower inflammatory factor levels,and higher arterial partial pressure of oxygen after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Glucocorticoids can reduce lymphocyte levels,improve pulmonary function,increase arterial partial pressure of oxygen,and decrease arterial partial pressure of carbon dioxide and inflammatory factor levels in AECOPD patients,with a good safety profile.
Keywords：glucocorticoidchronic obstructive pulmonary diseaseacute exacerbationlymphocytes
Publication Date：2025-11-20
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：5( 160-164 )