Analysis of Risk Factors and Construction of A Prediction Model for Postoperative Malnutrition in Patients with Laryngeal Cancer
JI Lirong
LIN Rui
GAO Junfang
TAN Min
GU Zijun
LU Zhaoyi
DING Qiuwen
ZHOU Han
Abstract：Objective To analyze the risk factors for postoperative malnutrition in patients with laryngeal cancer and to construct a risk prediction model.Methods A total of 202 patients with laryngeal cancer treated at the First Affiliated Hospital of Nanjing Medical University from January 2022 to July 2024 were retrospectively selected and divided into a malnutrition group(n=64)and a well-nourished group(n=138)based on the occurrence of postoperative malnutrition.Multivariate logistic regression was used to analyze the influencing factors of malnutrition;a nomogram model for malnutrition was constructed,and its predictive value was evaluated using the receiver operating characteristic curve.Results The malnutrition group had a higher proportion of patients aged≥60 years,with a monthly household income per capita<3 000 yuan,clinical stage(Ⅲ-Ⅳ),total laryngectomy,neck lymph node dissection,and postoperative complications,while body mass index(BMI),hemoglobin,total protein,and albumin levels were lower than those in the well-nourished group(P<0.05).Multivariate analysis showed that age≥60 years(OR=1.998,95%CI:1.415-2.821),low BMI(OR=0.490,95%CI:0.345-0.694),clinical stage(Ⅲ-Ⅳ)(OR=2.361,95%CI:1.583-3.521),and low albumin level(OR=0.331,95%CI:0.213-0.516)were independent risk factors for postoperative malnutrition in patients with laryngeal cancer(P<0.05).The constructed nomogram model for predicting postoperative malnutrition in laryngeal cancer patients showed a consistency index(C-index)of 0.873(95%CI:0.821-0.925).The area under the curve(95%CI)for predicting postoperative malnutrition in laryngeal cancer patients was 0.881(0.829-0.933),with a specificity of 0.682 and a sensitivity of 0.916.Conclusion The nomogram model for predicting postoperative malnutrition in patients with laryngeal cancer,based on age,BMI,clinical stage,and albumin level,demonstrates good predictive performance and clinical application value.
Keywords：laryngeal cancermalnutritionrisk factorsnomogramprediction model
Publication Date：2025-11-20
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：6( 108-113 )