Association Between MTHFR C677T Gene Variant and Clinical Outcomes in Elderly Patients with H-type Hypertensive Cerebral Infarction
MA Lingyun
BIAN Fengquan
FENG Haijun
DING Guobin
HE Shigui
YIN Yi
ZHAO Kepeng
Abstract：Objective To investigate the correlation between methylenetetrahydrofolate reductase(MTHFR)C677T gene variant and clinical outcomes in elderly patients with H-type hypertensive cerebral infarction.Methods A total of 152 elderly patients with H-type hypertensive cerebral infarction admitted to Taixing People's Hospital from December 2022 to December 2024 were prospectively enrolled.All patients received standardized treatment.The MTHFR C677T gene variant and homocysteine(Hcy)level were detected before treatment,and clinical data of the patients were collected.After treatment,the patients were followed up for half a year to evaluate their clinical outcomes.Logistic regression analysis was used to analyze the factors associated with clinical outcomes in elderly patients with H-type hypertensive cerebral infarction.Results Among the 152 elderly patients with H-type hypertensive cerebral infarction in this study,there were 34 patients with poor clinical outcomes and 118 patients with good clinical outcomes during the follow-up period.They were assigned to the poor outcome group(n=34)and the good outcome group(n=118),respectively.Compared with the good outcome group,the poor outcome group had higher proportions of CT and TT genotypes of the MTHFR C677T gene,Hcy level,systolic and diastolic blood pressure,NIHSS score,and larger lesion diameter(P<0.05).Logistic regression analysis showed that factors associated with clinical outcomes in elderly patients with H-type hypertensive cerebral infarction included MTHFR C677T genotype(OR=1.408,95%CI:1.106-1.792),Hcy level(OR=1.065,95%CI:1.018-1.114),and NIHSS score(OR=1.044,95%CI:1.012-1.077).Conclusion MTHFR C677T gene variant,Hcy level,and NIHSS score are associated with clinical outcomes in elderly patients with H-type hypertensive cerebral infarction.
Keywords：epigeneticsmethylenetetrahydrofolate reductase C677T geneelderlyH-type hypertensioncerebral infarction
Publication Date：2025-11-20
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：5( 98-102 )