Analysis of the Impact of Pain on Cancer-Related Fatigue and Quality of Life in Elderly Patients with Malignant Tumors and Influencing Factors for Poor Pain Control
SHAO Peipei
CHEN Huaqing
GU Dou
ZHI Ying
TANG Jingmi
Abstract：Objective To analyze the influence of pain on cancer-related fatigue and quality of life in elderly patients with malignant tumors and the influencing factors of poor pain control.Methods A total of 302 elderly patients with malignant tumors treated at the Affiliated Huai'an First People's Hospital of Nanjing Medical University from March 2023 to March 2024 were retrospectively selected.They were assessed using the Brief Pain Inventory(BPI),the Cancer-Related Fatigue Self-Assessment Scale,and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30)at admission.Based on BPI scores,patients were divided into a mild pain group(134 cases)and a moderate-to-severe pain group(168 cases).The EORTC QLQ-C30 and Piper Fatigue Scale scores were compared between the two groups at admission.Multivariate Logistic regression was used to analyze the influencing factors of poor pain control in elderly patients with malignant tumors.Results The total scores of the BPI,Piper Fatigue Scale,EORTC QLQ-C30 functional domain,and EORTC QLQ-C30 symptom domain in the 302 elderly patients with malignant tumors at admission were(8.90±1.11)points,(18.22±2.32)points,(76.39±10.05)points,and(71.94±7.95)points,respectively.The mild pain group had significantly lower scores in all dimensions and total score of the Piper Fatigue Scale,as well as the total score of the EORTC QLQ-C30 symptom domain,compared to the moderate-to-severe pain group,while the total score of the EORTC QLQ-C30 functional domain was significantly higher than that of the moderate-to-severe pain group(P<0.05).Multivariate Logistic regression analysis showed that TNM stage Ⅲ-Ⅳ,Piper Fatigue Scale score≥5 points,comorbid depression,comorbid anxiety,non-adherence to analgesic medication,rural residence,comorbid sleep disorders,tumor invasion and compression of surrounding tissues and organs,chemotherapy-induced peripheral neuropathy,and surgical nerve injury were risk factors for poor pain control in elderly patients with malignant tumors(OR=2.069,95%CI:1.094-3.912,P=0.026;OR=3.028,95%CI:1.729-5.305,P<0.01;OR=1.876,95%CI:1.176-2.991,P=0.009;OR=3.786,95%CI:1.097-3.786,P=0.025;OR=3.800,95%CI:1.319-10.951,P=0.014;OR=2.179,95%CI:1.244-3.817,P=0.007;OR=1.891,95%CI:1.138-3.141,P=0.014;OR=3.611,95%CI:1.555-8.388,P=0.003;OR=2.307,95%CI:1.419-3.751,P=0.001;OR=2.106,95%CI:1.332-3.332,P=0.002;OR=2.680,95%CI:1.090-6.591,P=0.032).Conclusion TNM stage Ⅲ-Ⅳ,Piper Fatigue Scale score≥5 points,comorbid depression,comorbid anxiety,non-adherence to analgesic medication,rural residence,comorbid sleep disorders,tumor invasion and compression of surrounding tissues and organs,chemotherapy-induced peripheral neuropathy,and surgical nerve injury are risk factors influencing poor pain control in elderly patients with malignant tumors.
Keywords：malignant tumorelderlypaincancer-related fatiguequality of life
Publication Date：2025-11-20
Online Publishing Date：2025-11-24(First online date of this platform, not the publication date of the document)
Pages：6( 56-61 )