Study on the Characteristics of Coagulation Function Indicators and their Potential Clinical Significance in Breast Cancer Patients

GU Yawen; PAN Chi; NI Qingtao

doi:10.3639/j.issn.2095-3097.2025.10.021

Abstract：Objective This study aimed to investigate changes in coagulation parameters and evaluate their clinical application value in breast cancer patients.Methods A retrospective study was conducted on 220 patients with breast cancer and 38 patients with benign breast diseases admitted to the Affiliated Taizhou People's Hospital of Nanjing Medical University between September 2015 and May 2021.Coagulation parameters—fibrinogen,prothrombin time(PT),international normalized ratio(INR),thrombin time(TT),and activated partial thromboplastin time(APTT)—were compared between the two groups,as well as among breast cancer patients with different stages and pathological types.Multivariate logistic regression analysis was used to evaluate the independent association between coagulation parameters and breast cancer risk.Results Compared with the benign breast disease group,the breast cancer group showed increased fibrinogen levels,elevated INR,prolonged PT(P<0.05),and shortened TT(P<0.05).No significant difference was observed in APTT between the two groups(P>0.05).Fibrinogen levels were lower in patients with stage 0-Ⅰ breast cancer than in those with stage Ⅱ-Ⅳ disease(P<0.05).Patients with carcinoma in situ had longer TT than those with invasive carcinoma(P<0.05).Multivariate logistic regression analysis identified TT as an independent risk factor for breast cancer(OR=1.891,95%CI:1.248-2.865,P=0.003).Each 1-second increase in TT was associated with an 89.1%increase in breast cancer risk.Conclusion Breast cancer patients exhibit abnormal coagulation function,which is correlated with the occurrence,development,and pathological progression of breast cancer.