The Predictive Value of Systemic Immune-Inflammation Index for Prognosis in Elderly Patients with Heart Failure with Mid-Range Ejection Fraction
WANG Xiaowen
LI Fengjie
JIANG Zhifeng
WANG Haotian
ZHANG Bo
Abstract：Objective To analyze the predictive value of the systemic immune-inflammation index(SII)for the prognosis of elderly patients with heart failure with mid-range ejection fraction(HFmrEF).Methods A total of 152 elderly patients with HFmrEF admitted to Beijing Luhe Hospital,Capital Medical University from November 2019 to April 2024 were selected as the study subjects.Based on the one-year follow-up results,they were divided into a poor prognosis group(n=44)and a good prognosis group(n=108).After admission,all patients underwent measurements of platelet count(PLT),neutrophil count(NEUT),lymphocyte count,and related indicators,and SII was calculated.General data and SII were compared between the two groups.The predictive value of SII for the prognosis of elderly HFmrEF patients was evaluated using receiver operating characteristic(ROC)curve analysis,and multivariate logistic regression was used to analyze factors influencing prognosis.Results The poor prognosis group had higher NYHA cardiac function classification,creatine kinase isoenzyme,high-sensitivity C-reactive protein(hs-CRP),cystatin C(Cys C),N-terminal pro-brain natriuretic peptide(NT-proBNP),PLT,NEUT,neutrophil-to-lymphocyte ratio(NLR),and SII levels compared to the good prognosis group(P<0.05),while LC and left ventricular ejection fraction(LVEF)were lower(P<0.05).ROC curve analysis showed that the areas under the curve(95%CI)of PLT,NLR,and SII for predicting poor prognosis in elderly HFmrEF patients were 0.847(0.797-0.897),0.858(0.808-0.908),and 0.902(0.852-0.952),respectively.DeLong's test revealed that the predictive efficacy of SII was significantly better than that of PLT and NLR(Z=2.341,2.018,both P<0.05).Multivariate logistic regression analysis indicated that peripheral blood hs-CRP>5.68 mg/L(OR=2.423),Cys C>1.33 mg/L(OR=1.790),NT-proBNP>1 286.62 pg/mL(OR=3.404),and SII>1 220.22(OR=2.776)were risk factors for poor prognosis in elderly HFmrEF patients(P<0.05).Conclusion SII is closely associated with the prognosis of elderly HFmrEF patients and can effectively predict the occurrence of poor prognosis.
Keywords：heart failuremid-range ejection fractionsystemic immune-inflammation indexelderlyprognosis
Publication Date：2025-10-20
Online Publishing Date：2025-10-28(First online date of this platform, not the publication date of the document)
Pages：5( 34-38 )