Exploration of the Value of CT-FFR,TyG Index,and NLR in Assessing the Degree of Coronary Artery Stenosis in Elderly Patients with Coronary Heart Disease
PAN Dabin
PAN Jianyuan
ZHA Lintao
LING Yang
HU Sisi
ZUO Quan
Abstract：Objective To investigate the value of CT-derived fractional flow reserve(CT-FFR),triglyceride-glucose(TyG)index,and neutrophil-to-lymphocyte ratio(NLR)in evaluating the degree of coronary artery stenosis in elderly patients with coronary heart disease(CHD).Methods A retrospective study included 80 elderly CHD patients admitted to Yijishan Hospital of Wannan Medical College from January 2021 to October 2024.Patients were classified into a mild group(n=42)and a moderate-to-severe group(n=38)based on Gensini scores.General data,CT angiography parameters,blood lipid levels,TyG index,and inflammatory markers were compared between groups.Correlations of CT-FFR,TyG index,and NLR with Gensini scores and coronary artery calcification(CAC)scores were analyzed.Receiver operating characteristic(ROC)curves were plotted to evaluate the combined utility of CT-FFR,TyG,and NLR in assessing coronary stenosis severity.Multivariate logistic regression identified factors influencing stenosis severity.Results The moderate-to-severe group had significantly higher Gensini scores,CAC scores,coronary stenosis severity,TyG index,and NLR(P<0.05),but lower CT-FFR than the mild group(P<0.05).CT-FFR showed negative correlations with Gensini and CAC scores,while TyG index and NLR showed positive correlations(P<0.05).The combined detection of CT-FFR,TyG,and NLR yielded an AUC of 0.900 for evaluating stenosis severity,with sensitivity 0.816,specificity 0.905,and Youden index 0.721-all superior to individual markers.High TyG index,NLR,and CAC scores were independent risk factors for severe stenosis(P<0.05),whereas high CT-FFR was a protective factor(P<0.05).Conclusion CT-FFR,TyG index,and NLR demonstrate high clinical value in assessing coronary stenosis severity in elderly CHD patients.CT-FFR negatively correlates with Gensini and CAC scores,while TyG index and NLR show positive correlations.Combined assessment of these markers provides comprehensive guidance for clinical management.
Keywords：coronary heart diseaseCT myocardial perfusion reserve indexblood lipidstriglyceride-glucose indexneutrophil to lymphocyte ratiodegree of coronary artery stenosis
Publication Date：2025-08-20
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：5( 63-67 )