Influence of Sufentanil Combined with Different Doses of Ropivacaine for PIEB on Labor Process and Neonatal Apgar Score in Parturients Undergoing Labor Analgesia
CHEN Tang
WANG Yixuan
BAI Jie
WU Gang
Abstract：Objective To explore the influence of combined application of sufentanil and different doses of ropivacaine for analgesia on labor process and neonatal Apgar score in parturients.Methods A total of 68 primiparas requiring analge-sic intervention during delivery at the Second Affiliated Hospital of Xi'an Jiaotong University from January 2023 to December 2024 were randomly divided into high-dose group(34 cases)and low-dose group(34 cases)using a random number ta-ble.Both groups received analgesia via programmed intermittent epidural bolus(PIEB)followed by patient-controlled epidural analgesia(PCEA).The PIEB analgesic solution for the high-dose group was 0.1%ropivacaine+0.5 μg/mL sufentanil,and for the low-dose group was 0.08%ropivacaine+0.5 μg/mL sufentanil.Maternal visual analogue scale(VAS)scores were com-pared between groups immediately after lateral positioning(T0),at cervical dilation to 2 cm(T1),4 cm(T2),6 cm(T3),8 cm(T4),and full dilation(T5).Analgesic drug consumption,number of PCEA compressions,labor stages(first,second,and third stag-es),duration of analgesia,neonatal Apgar score at 5 min after birth,and incidence of adverse drug reactions during analgesia were compared.Results VAS scores at T1-T5 were significantly lower than at T0 in both groups(P<0.05),with no signifi-cant difference between groups at any same time point(P>0.05).The low-dose group had significantly higher total sufentanil consumption and more PCEA compressions than the high-dose group[(39.87±6.49)mg vs(35.23±6.56)mg;(10.09±2.31)times vs(8.52±2.29)times,P<0.05].The incidence of adverse drug reactions did not differ significantly between groups(8.82%vs 5.88%,P>0.05).Conclusion Different doses of ropivacaine under PIEB provide effective analgesia.Maintaining ropivacaine at 0.1%reduces sufentanil consumption and PCEA compressions,thereby improving the analgesic experience for parturients.
Keywords：SufentanilRopivacaineProgrammed intermittent epidural bolusPatient-controlled epidural analgesiaLabor analgesiaDelivery outcomes
Publication Date：2025-07-20
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：4( 170-173 )