Effects of Calcium Dobesilate Combined with Calcitriol on Oxidative Stress,Microinflammatory Status and Coronary Artery Calcification in Diabetic Nephropathy Patients
AERPATI·Abulitibu
WANG Shun
HAN Yuanyuan
MUFUNAYI·Aierken
MAO Zhijie
KANG Shaotao
LIU Xinpeng
Abstract：Objective To observe the effect of calcium dobesilate combined with calcitriol on oxidative stress,mi-croinflammatory status,and coronary artery calcification in diabetic nephropathy(DN)patients.Methods Fifty patients with DN admitted to the First Affiliated Hospital of Xinjiang Medical University from May 2023 to March 2024 were selected.Using the sealed envelope randomization method,the subjects were randomly assigned to the monotherapy group(calcitriol alone,25 cases)and the combined therapy group(calcium dobesilate combined with calcitriol,25 cases).Comparison be-tween the two groups was made on renal function[blood urea nitrogen(BUN)and serum creatinine(Scr)],oxidative stress[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)],microinflammatory status[high-sensitivity C-reactive pro-tein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)],coronary artery calcium score(CACS),and adverse reactions.Results After treatment,the levels of BUN[(4.13±0.87)mmol/L],Scr[(71.84±7.51)μmol/L],hs-CRP[(5.92±1.01)mg/L],IL-6[(0.42±0.05)ng/L],TNF-α[(6.32±0.89)μg/L],and CACS[(64.28±4.97)points]in the combina-tion therapy group were significantly lower than those in the monotherapy group[(4.81±1.01)mmol/L,(79.26±8.25)μmol/L,(6.81±1.09)mg/L,(0.51±0.09)ng/L,(6.98±1.04)μg/L,and(72.31±5.23)points,respectively].The levels of SOD[(126.21±11.81)U/mL]and GSH-Px[(121.43±12.06)U/L]in the combination therapy group were higher than those in the monotherapy group[(107.65±10.72)U/mL and(112.59±11.48)U/L,respectively],and the differences were statistically sig-nificant(P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined use of calcium dobesilate and calcitriol can significantly improve renal function,oxidative stress,and microinflammatory status in DN patients,while also delaying coronary artery calcification,with good safety.
Keywords：Calcium dobesilateCalcitriolDiabetic nephropathyOxidative stressMicro-inflamation statusCoronary artery calcification
Publication Date：2025-07-20
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：5( 160-164 )