Efficacy of Ultra-pulsed CO2 Fractional Laser Combined with Photorejuvenation in the Treatment of Atrophic Acne Scars and Its Influence on Skin Barrier,Scar Area and ECCA Score
SUN Xiaohong
QIN Xiumei
MA Haili
LIU Xiaoliang
JIANG Meiyu
LI Luxiao
Abstract：Objective To observe the efficacy of ultra-pulsed CO2 fractional laser combined with photorejuvenation in the treatment of atrophic acne scars and its effects on skin barrier indicators,scar area,and Echelle d'évaluation clinique des cicatrices d'acné(ECCA)score.Methods A total of 148 patients with atrophic acne scars treated at Yantai Mountain Hospital were selected from September 2022 to September 2024.They were divided into a combined group(74 cases)and a control group(74 cases)using a random number table.The control group received ultra-pulsed CO2 fractional laser treatment,while the combined group received photorejuvenation 2 weeks after the ultra-pulsed CO2 fractional laser treatment.Both groups underwent 3 treatment sessions at 4-week intervals.Clinical efficacy at 3 months after the final treatment,skin barrier function,scar area,ECCA score,skin chroma,and adverse reaction Incidence were compared between the two groups before and after treatment.Results At 3 months post-treatment,the total effective rate was higher in the combined group than in the control group(P<0.05).Transepidermal water loss(TEWL),ECCA scores,and skin chroma a* values significantly decreased in both groups compared to pretreatment levels(P<0.05),with the combined group showing lower values than the control group(P<0.05).Stratum corneum hydration(SCH)and skin chroma L* values increased compared to pretreatment levels(P<0.05),with higher values in the combined group(P<0.05).Scar area significantly decreased in both groups(P<0.05),with a smaller area in the combined group(P<0.05).The incidence of pigmentation was lower in the combined group than in the control group(P<0.05).Conclusion Ultra-pulsed CO2 fractional laser combined with photorejuvenation is effective for treating atrophic acne scars.It better improves skin barrier function,reduces scar area,lowers ECCA scores,improves skin chroma,and decreases the risk of pigmentation,demonstrating good safety.
Keywords：Atrophic acne scarsUltra-pulsed CO2 fractional laserPhotorejuvenationSkin barrierEchelle d'évaluation clinique des cicatrices d'acné
Publication Date：2025-07-20
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：4( 117-120 )