The Relationship between Serum IL-10 and BNP Levels and the Severity and Coronary Artery Lesions of Kawasaki Disease in Children

XIA Kun; ZHANG Yong; ZHOU Dan; FU Jia; ZHANG Huayong

doi:10.3639/j.issn.2095-3097.2025.07.014

Abstract：Objective To explore the relationship between serum interleukin-10(IL-10)and B-type natriuretic peptide(BNP)levels and the severity of Kawasaki disease(KD)and coronary artery lesions(CAL)in children.Methods A total of 120 children with KD admitted to Tongji Hospital of Wuhan Children's Hospital,Huazhong University of Science and Technology from November 2021 to December 2023 were selected as the study group,and another 60 healthy children undergoing physical examinations during the same period were selected as the control group.The study group was divided into the CAL group(37 cases)and the non-CAL group(83 cases)based on the presence or absence of CAL.The CAL group was further divided into the mild group(16 cases),the moderate group(12 cases),and the severe group(9 cases)based on CAL severity.Serum IL-10 and BNP levels were detected in all subjects.The predictive value of serum IL-10 and BNP levels for CAL occurrence in children with KD was analyzed using the receiver operating characteristic(ROC)curve.Multivariate Logistic stepwise regression was used to analyze influencing factors for CAL in children with KD.Results Serum IL-10 and BNP levels in the study group were higher than those in the control group(P<0.05).Serum IL-10 level in the CAL group was lower than that in the non-CAL group,while BNP level and coronary artery diameter were higher than those in the non-CAL group(P<0.05).Serum IL-10 was negatively correlated with coronary artery diameter in children with KD,while serum BNP was positively correlated with coronary artery diameter(P<0.05).The area under the curve(AUC)for combined serum IL-10 and BNP in predicting CAL occurrence in children with KD was 0.903,significantly higher than the AUCs for IL-10(0.724)and BNP(0.857)alone(P<0.05).Serum IL-10 levels in the moderate and severe groups were lower than those in the mild group,while serum BNP levels were higher than those in the mild group(P<0.05);serum IL-10 in the severe group was lower than that in the moderate group,and serum BNP was higher than that in the moderate group(P<0.05).Multivariate analysis showed that long fever duration,high CRP,and high BNP were independent risk factors for CAL in children with KD(P<0.05),while high IL-10 was an independent protective factor(P<0.05).Conclusion Serum IL-10 and BNP levels in children with KD are closely related to the occurrence and severity of CAL.Combined detection of serum IL-10 and BNP levels can predict CAL occurrence.