Clinical Value of Serum KLK6 and α-syn in Predicting Cognitive Dysfunction after Ischemic Stroke

WU Yaxin; YU Liping; KONG Wei; CHEN Peng; PAN Huan; ZHAO Jinhua

doi:10.3639/j.issn.2095-3097.2025.07.013

Abstract：Objective To explore the clinical value of serum kallikrein 6(KLK6)and α-synuclein(α-syn)in predicting cognitive dysfunction after ischemic stroke(iPSCI).Methods A retrospective selection was made of 196 patients with ischemic stroke admitted to the First People's Hospital of Xianyang from January 2020 to June 2024,among whom 72 cases developed iPSCI(cognitive impairment group)and 124 cases had normal cognitive function(cognitive normal group).The levels of serum KLK6 and α-syn and baseline data at admission of the two groups at admission were compared.The receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of serum KLK6,α-syn and their combination for iPSCI.The influencing factors of iPSCI were explored by multivariate Logistic stepwise regression analysis.Results The levels of serum KLK6 and α-syn in the cognitive impairment group were higher than those in the cognitive normal group(P<0.05).The AUC(95%CI)of serum KLK6,α-syn and their combination for predicting iPSCI were 0.843(0.793-0.893),0.716(0.671-0.766),and 0.922(0.877-0.972),respectively.Multivariate analysis showed that smoking history(OR=2.042,95%CI:1.117-3.735),hypertension(OR=2.354,95%CI:1.190-4.656),NIHSS score at admission(OR=2.841,95%CI:1.384-5.832),serum KLK6 level(OR=3.777,95%CI:1.963-7.269),and serum α-syn level(OR=3.111,95%CI:1.840-5.261)were independent risk factors for iPSCI(P<0.05).Conclusion The levels of serum KLK6 and α-syn at admission are significantly correlated with the occurrence of iPSCI.The combined detection of the two has a high predictive value and can be used as potential biomarkers for the early identification of high-risk patients with iPSCI.