Relationship between Levels of Peripheral Blood UA,GGT and YKL-40 and Short-Term Prognosis in Patients with Acute Cerebral Infarction
YAN Yuying
ZHANG Qiuxia
LIU Yong
LI Yuhang
WANG Min
Abstract：Objective To investigate the relationship between peripheral blood uric acid(UA),gamma glutamyl transferase(GGT)and chitinase-3-like protein 1(YKL-40)levels and short-term prognosis in patients with acute cerebral infarction.Methods A total of 200 patients with acute cerebral infarction admitted to Jieshou People's Hospital from December 2020 to December 2024 were selected as the cerebral infarction group,and 150 healthy volunteers were enrolled as the healthy group.The general clinical data and peripheral blood UA,GGT,and YKL-40 levels were compared.Pearson's correlation analysis was used to analyze the correlation between peripheral blood UA,GGT,YKL-40 levels and albumin,white blood cell count,neutrophils,fibrin degradation products,and infarct site.Patients were divided into a poor prognosis group(62 cases)and a good prognosis group(138 cases)based on 30-day post-onset outcomes.Their peripheral blood UA,GGT,and YKL-40 levels were compared.Multivariate Logistic regression identified factors influencing poor short-term prognosis,and the predictive value of UA,GGT,and YKL-40 was evaluated using the ROC curve.Results The white blood cell count,neutrophil,and fibrin degradation products in the cerebral infarction group were higher than those in the healthy group,while albumin was lower,with statistically significant differences(P<0.05).Peripheral blood UA,GGT,and YKL-40 levels were higher in the cerebral infarction group than in the healthy group[(350.24±62.19)μmol/L vs(275.42±50.28)μmol/L,(54.82±12.27)U/L vs(32.02±7.01)U/L,(34.05±7.68)ng/mL vs(24.05±3.53)ng/mL,P<0.05].Peripheral blood UA,GGT,and YKL-40 levels were significantly positively correlated with white blood cell count,neutrophil,and fibrin degradation products,and significantly negatively correlated with albumin(P<0.05).Peripheral blood UA,GGT,and YKL-40 levels in the poor prognosis group were significantly higher than those in the good prognosis group[(380.34±60.39)μmol/L vs(336.72±63.45)μmol/L,(58.93±10.56)U/L vs(52.97±12.73)U/L,(37.41±6.89)ng/mL vs(32.54±7.07)ng/mL,P<0.05].Multivariate Logistic regression analysis showed that peripheral blood UA,GGT,and YKL-40 levels were associated with short-term prognosis in acute cerebral infarction patients(OR=1.028,95%CI:1.016-1.041,P<0.001;OR=1.014,95%CI:1.002-1.026,P=0.020;OR=1.115,95%CI:1.005-1.237,P=0.040).The AUC of combined detection for predicting short-term prognosis was 0.823,significantly higher than that of UA(0.727),GGT(0.654),and YKL-40(0.691)alone(Z=3.311,3.876,3.652,P<0.05).Conclusion Peripheral blood UA,GGT,and YKL-40 levels in acute cerebral infarction patients were significantly higher than those in healthy individuals.Moreover,abnormally elevated levels of these markers could predict short-term poor prognosis in acute cerebral infarction patients,with combined detection offering superior predictive value.This suggests their potential involvement in the pathogenesis and progression of acute cerebral infarction.
Keywords：Acute cerebral infarctionUric acidGamma glutamyl transferaseChitinase protein 40
Publication Date：2025-07-20
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：6( 52-57 )