The Predictive Value of Serum Ficolin-3 and C5b-9 for Poor Prognosis in Elderly Patients with Chronic Heart Failure Complicated with Pulmonary Infection

HUANG Kun; ZHANG Hongli; XU Jingjing; SHI Yanxia; ZHANG Chunlai

doi:10.3639/j.issn.2095-3097.2025.07.004

Abstract：Objective To analyze the predictive value of serum Ficolin-3 and C5b-9 for poor prognosis in elderly patients with chronic heart failure(CHF)complicated with pulmonary infection.Methods A total of 220 elderly patients with CHF complicated with pulmonary infection who received treatment at Tangshan Central Hospital from October 2022 to October 2024 were selected.According to the prognosis during the follow-up period,the patients were divided into the poor prognosis group(59 cases)and the good prognosis group(161 cases).The differences in general data,Ficolin-3 and C5b-9 between the two groups were compared.The influencing factors of poor prognosis in elderly CHF patients with pulmonary infection were investigated by multivariate logistic stepwise regression analysis.The predictive value of Ficolin-3 and C5b-9 for poor prog-nosis in elderly CHF patients with pulmonary infection was evaluated using the area under the receiver operating character-istic(ROC)curve(AUC).Results The serum Ficolin-3 level in the poor prognosis group was significantly lower than that in the good prognosis group,and the serum C5b-9 level was significantly higher than that in the good prognosis group[(13.47±2.30)μg/mL vs(18.72±3.51)μg/mL;(297.25±19.46)ng/mL vs(232.84±17.58)ng/mL,P<0.05].Multivariate Logistic step-wise regression analysis showed that NYHA cardiac function class Ⅲ-Ⅳ,invasive procedures,elevated procalcitonin,and C5b-9≥265.05 ng/mL were independent risk factors for poor prognosis in elderly patients(OR=2.795,95%CI:1.405-5.562,P=0.003;OR=2.861,95%CI:1.528-5.356,P=0.001;OR=1.850,95%CI:1.209-2.830,P=0.005;OR=2.793,95%CI:1.443-5.406,P=0.002);Ficolin-3≥16.10 μg/mL was an independent protective factor(OR=0.393,95%CI:0.225-0.686,P=0.001).The AUC for predicting poor prognosis using the combination of Ficolin-3 and C5b-9 was 0.907,significantly higher than the AUC values of 0.784 and 0.856 for Ficolin-3 and C5b-9 alone,respectively(Z=10.072,9.864,P<0.001).Conclusion De-creased Ficolin-3 and elevated C5b-9 are closely related to poor prognosis in elderly patients with CHF complicated with pulmonary infection.The predictive value of combined detection is significantly better than that of single detection,and they can serve as biomarkers for prognosis assessment.