Predictive Value of Thromboelastography,PDW and DFR Levels for Pulmonary Embolism in AECOPD
XING Ningning
WANG Junchang
LI Hui
HOU Weili
FAN Yanqing
Abstract：Objective To explore the predictive value of thromboelastography(TEG),platelet distribution width(PDW),and D-dimer/fibrinogen ratio(DFR)for coexisting pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 130 AECOPD patients admitted to Xingtai Central Hospital from April 2023 to May 2024 were enrolled.Patients were divided into an embolism group(n=58)and a non-embolism group(n=72)based on the occurrence of pulmonary embolism.Baseline characteristics,TEG parameters,PDW,DFR and platelet count(PLT)were compared between groups.Pearson correlation was used to analyze relationships between TEG parameters and PDW,DFR,and PLT.Binary logistic regression identified factors associated with pulmonary embolism in AECOPD.Re-ceiver operating characteristic(ROC)curves evaluated the predictive value of TEG parameters,PDW,and DFR for pulmonary embolism in AECOPD.Results Compared to the non-embolism group,patients in the embolism group exhibited signifi-cantly higher proportions of smoking history,PLT,TEG parameters including maximum amplitude(MA)and α-angle,PDW,and DFR(P<0.05),while R-time and K-time were significantly lower(P<0.05).MA and α-angle showed significant positive correlations with PDW,DFR,and PLT levels(P<0.05),whereas K-time and R-time showed significant negative correlations with PDW,DFR,and PLT levels(P<0.05).Binary logistic regression analysis showed that TEG parameters(K-time,R-time,MA,α-angle),PDW,and DFR were all independent influencing factors significantly associated with pulmonary embolism in AECOPD patients(P<0.05).ROC curve analysis indicated that the AUC values for MA,K-time,R-time,α-angle,PDW,and DFR in predicting pulmonary embolism in AECOPD were 0.706,0.738,0.713,0.700,0.723,and 0.729,respectively.The combination of these six indicators achieved significantly enhanced predictive efficacy,with an AUC of 0.973,89.66%sen-sitivity,and 54.17%specificity.Conclusion Abnormal TEG parameters,PDW and DFR may indicate coexisting pulmonary embolism in AECOPD patients.
Keywords：Chronic obstructive pulmonary diseasePulmonary embolismThromboelastographyPlatelet distribution widthD-dimerFibrinogen
Publication Date：2025-07-20
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：6( 7-12 )