Effects of Oxycodone-Acetaminophen Tablets and Morphine Hydrochloride Tablets on Breakthrough Pain and Serum Inflammatory Factors in Elderly Opioid-Tolerant Cancer Pain Patients
ZHANG Lei
CHEN Xiaoyan
SUI Lili
QIAN Liwen
HOU Xinyu
Abstract：Objective To investigate the effects of oxycodone-acetaminophen tablets and morphine hydrochloride tab-lets on breakthrough pain and serum inflammatory factors in elderly patients with opioid tolerance to cancer pain.Methods A total of 122 elderly opioid-tolerant cancer pain patients admitted to Shunyi Hospital,Beijing from October 2023 to October 2024 were divided into group A(morphine hydrochloride tablets for analgesia,n=61)and group B(oxycodone-acetaminophen tablets for analgesia,n=61)using the random envelope method.After 2 weeks of treatment,the following were compared:breakthrough pain relief time,pain intensity[Numerical Rating Scale(NRS)],serum inflammatory factors[interleukin-6(IL-6),tumor necro-sis factor-α(TNF-α),IL-1β,chemokine ligand 12(CXCL12)],quality of life[Chinese version of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 version 3.0(EORTC QLQ-C30)],performance status[Eastern Cooperative Oncology Group Performance Status(ECOG-PS)],and adverse reaction incidence.Results The relief time of breakthrough pain in group B was shorter than that in group A(P<0.05).NRS score showed statistically significant differences in groups,timepoint,and interaction effects(P<0.05).NRS score decreased over time in both groups(P<0.05),and were lower in group B than group A at pre-medication(T0),5 min(T1),15 min(T2),30 min(T3),and 60 min(T4)post-medication(P<0.05).After 2 weeks,IL-6,TNF-α,IL-1β and CXCL12 levels decreased in both groups,with lower levels in group B than group A(P<0.05).EORTC QLQ-C30 scores of patients in both groups were increased,and group B was higher than group A(P<0.05);ECOG-PS scores decreased,with lower scores in group B than group A(P<0.05).No significant difference in adverse reactions incidence was observed between the two groups(P>0.05).Conclusion Both oxycodone-acetaminophen tablets and morphine hydrochlo-ride tablets effectively control breakthrough pain in elderly opioid-tolerant cancer pain patients.Oxycodone-acetaminophen tab-let demonstrate superior efficacy in reducing inflammation,accelerating breakthrough pain relief,decreasing pain intensity,im-proving quality of life,and enhancing performance status while maintaining comparable safety to morphine hydrochloride tablets.
Keywords：Oxycodone-Acetaminophen tabletsMorphine hydrochloride tabletsAdvanced ageOpioidsToleranceCancer painInflammatory factorsBreakthrough pain
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 135-140 )