The Predictive Value of Serum β2-MG and CRP/ALB for Acute Recurrence after Treatment in Patients with Acute Exacerbation of Bronchial Asthma
HE Hantao
JIANG Chen
HONG Yuze
WANG Xiaolong
WANG Xiaoyao
Abstract：Objective To analyze the predictive value of serum β2-microglobulin(β2-MG)and C-reactive protein/albumin(CRP/ALB)for acute recurrence after treatment in patients with acute exacerbation of bronchial asthma.Methods A total of 126 patients with acute exacerbation of bronchial asthma admitted to our hospital from January 2021 to January 2024 were selected as research subjects and divided into a recurrence group(n=51)and a non-recurrence group(n=75)based on whether they had acute recurrence within one year after treatment.All included patients had their serum β2-MG,C-reactive protein(CRP),and albumin(ALB)levels measured upon admission,and CRP/ALB was calculated.General data,related biochemical indicators,and serum β2-MG and CRP/ALB were analyzed and compared between the groups.The predictive value of serum β2-MG and CRP/ALB for acute recurrence after treatment in patients with acute exacerbation of bronchial asthma was evaluated using ROC analy-sis.The factors influencing acute recurrence after treatment in patients were explored by multivariate logistic regression analysis.Results The recurrence group showed significantly higher disease duration,proportion of asthma family history,proportion of moderate-to-severe cases,neutrophil count,Th17/Treg ratio,CRP,CRP/ALB,and β2-MG levels than the non-recurrence group,while exhibiting lower Asthma Control Test(ACT)scores,FEV1/FVC ratio,and ALB levels(P<0.05).ROC curve analysis revealed that the AUC(95%CI)for serum CRP/ALB,β2-MG,and their combination in predicting post-treatment acute recurrence in bron-chial asthma patients were 0.838(0.788-0.881),0.850(0.800-0.900),and 0.902(0.852-0.952),respectively.The AUC for the combined(serial)diagnosis of β2-MG and CRP/ALB was significantly higher than that of either biomarker alone(Z=6.542,8.455;P<0.05).Multivariate logistic stepwise regression analysis identified ACT score<20.66(OR=1.944),FEV1/FVC<53.62%(OR=2.396),Th17/Treg≥1.38(OR=1.929),β2-MG≥4.95 mg/L(OR=3.543),and CRP/ALB≥1.86(OR=4.674)as inde-pendent risk factors for post-treatment acute recurrence(P<0.05).Conclusion Abnormal elevation of serum β2-MG and CRP/ALB is closely related to acute recurrence after treatment in patients with acute exacerbation of bronchial asthma.Both can ef-fectively predict acute recurrence after treatment.The combination of the two has a higher predictive value.
Keywords：Bronchial asthmaAcute exacerbationβ2-microglobulinC-reactive protein/albuminRecurrencePre-dictive value
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 30-35 )