Effect of Stereotactic Radiotherapy Combined with Percutaneous Pedicle Screw Fixation and Vertebroplasty versus Separation Surgery in the Treatment of Thoracolumbar Spinal Metastases
JIANG Ning
GUO Jun
LIU Cheng
GUO Wei
HAO Zhiya
Abstract：Objective To investigate the clinical effects of stereotactic radiotherapy combined with percutaneous pedicle screw(PPS)+percutaneous vertebraplasty(PVP)or separation surgery in the treatment of thoracolumbar spinal metas-tases.Methods This study retrospectively analyzed the clinical data of 83 patients with thoracolumbar spinal metastases who underwent elective surgical treatment at the 5th Medical Center of PLA General Hospital between May 2016 and May 2021.Patients were divided into group A(stereotactic radiotherapy combined with PPS+PVP,37 patients)and group B(stereotactic radiotherapy combined with separation surgery,46 patients)based on different surgical methods.Pain,vertebral function recov-ery,neurological function,and quality of life were compared between the two groups at multiple time points.There-year survival rates and overall survival were also analyzed.Results The visual analogue scale(VAS)scores,Oswestry disability index(ODI)scores,Frankel neurological function scores,and Karnofsky performance status(KPS)scores differed between the two groups at different time points(P<0.05).Group A had significantly lower VAS scores than group B at 1 week,1 month,3 months,and 6 months postoperatively(P<0.05).Group A had significantly higher ODI scores and significantly lower Frankel neurological function scores than group B at 6 and 12 months postoperatively(P<0.05).The KPS scores showed no significant differences be-tween the two groups at all time points(P>0.05).There were no significant differences in the 3-year survival rate,overall survival,tumor recurrence rate,or metastasis rate during follow-up between the two groups(P>0.05).Conclusion Stereotactic radiothera-py combined with separation surgery achieves better effects than stereotactic radiotherapy combined with PPS+PVP in promoting vertebral function recovery and in relieving spinal nerve compression.However,separation surgery is inferior for pain relief.
Keywords：Thoracolumbar spinal metastasisStereotactic radiotherapyPercutaneous pedicle screwPercutaneous ver-tebroplastySeparation surgeryClinical effect
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1-6 )