Efficacy of Nicorandil Combined with Dual Antiplatelet Therapy on Acute Myocardial Infarction and Its Influence on Serum BNP,IL-10 and NOS Levels
MI Jingjing
LI Chunxia
LI Jixia
HE Miao
MIAO Li
LIU Xin
Abstract：Objective To investigate the efficacy of nicorandil combined with dual antiplatelet therapy in the treatment of acute myocardial infarction(AMI)and its influence on serum brain natriuretic peptide(BNP),interleukin-10(IL-10)and ni-tric oxide synthase(NOS)levels.Methods One hundred and fifty-six patients with AMI in Yulin Hospital of the First Affiliated Hospital of Xi'an Jiaotong University from November 2023 to December 2024 were selected as study subjects,and grouped by random number table method,with 78 patients in each group.The control group received dual antiplatelet therapy(aspirin+tica-grelor),while the observation group was additionally treated with nicorandil on the basis of the control group.The occurrence of angina pectoris and dosage of nitroglycerin before and after treatment were recorded in both groups.Cardiac function[left ven-tricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)],myocardial markers[creatine kinase(CK),brain natriuretic peptide(BNP),cardiac troponin(cTnI)],vascular endothelial function[nitric oxide synthase(NOS),endothelin-1(ET-1)]and inflammatory factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),IL-10]were compared between the two groups before and after treatment.During treatment,the adverse reactions in the two groups were counted.Results After treatment,the levels of LVEF,NOS and IL-10 in observation group were higher than those in control group[(44.96±6.33)%vs(40.78±5.18)%,(245.73±15.50)vs(213.62±11.45)U/mL,(6.21±1.33)vs(5.72±1.06)pg/mL]while the duration of each attack,weekly attack frequency,weekly nitroglycerin dosage,LVEDD,CK,BNP,cTnI,ET-1,hs-CRP,TNF-α were lower compared to control group.During treatment,no statistical difference was observed in the incidence of adverse reactions between groups of patients[10.26%(8/78)vs 5.13%(4/78)](P>0.05).Conclusion Combined therapy with nicorandil and dual antiplatelet therapy has significant efficacy in the treatment of AMI,and it can improve cardiac function,re-lieve myocardial injury,inhibit the inflammatory response,and enhance the vascular endothelial function,with good safety.
Keywords：NicorandilAspirinTicagrelorAcute myocardial infarctionMyocardial markersVascular endothelial function
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 148-152 )