Analysis of the Prognosis Factors inFluencing Locally Advanced Esophageal Squamous Cell Carcinoma after Radical Synchronous Chemoradiation and Chemotherapy
WANG Jiangyan
LI An
GUO Xuejuan
Abstract：Objective To analyze the factors influencing the prognosis of patients with locally advanced esophageal squamous cell carcinoma(ESCC)after radical synchronous chemoradiotherapy.Methods A total of 173 ESCC patients who re-ceived radical synchronous chemoradiotherapy in the Oncology Department of our hospital from October 2016 to October 2019 were retrospectively selected as research subjects.The radiotherapy plan for all patients was three-dimensional conformal inten-sity-modulated radiotherapy,with concurrent platinum-based systemic chemotherapy.Clinical data were collected,and patients were followed up for 5 years.The log-rank test and multifactor Cox regression model were used to analyze influencing factors of OS and DFS in ESCC patients.The Kaplan-Meier method was used to calculate the survival curves for OS and DFS.Results As of the end of follow-up,the 3-and 5-year OS rates of the entire group were 54.91%and 35.84%,respectively,with a median OS of 40.6 months;the 3-and 5-year DFS were 43.93%and 29.48%,with a median DFS of 29.4 months.Multivariate Cox regres-sion analysis showed that tumor length,T stage,N stage,TNM stage,and prescription dose were independent factors affect-ing OS,while age,T stage,N stage,TNM stage,and prescription dose were independent factors affecting patient DFS(P<0.05).Conclusion Patients with locally advanced ESCC receiving radical synchronous chemoradiotherapy can achieve satisfactory sur-vival prognosis.Tumor length,T stage,N stage,TNM stage,and prescription dose are independent influencing factors for OS.Age,T stage,N stage,and TNM stage,prescription dose are an independent influencing factor for DFS.
Keywords：Esophageal squamous cell carcinomaRadiotherapy and chemotherapyPrognosisInfluencing factors analysis
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 97-100 )