Relationship between 18F-FDG PET/CT Quantitative Parameters and IWSI Infarct Area,Cognitive Dysfunction and Predictive Value Analysis
LI Peidang
LU Kai
MA Yu
Abstract：Objective To analyze the relationship between the quantitative parameters of 18F-deoxyglucose positron emission computed tomography(18F-FDG PET/CT)and the infarct area and cognitive dysfunction of internal watershed cerebral infarction(IWSI),and to analyze its prognostic value for patients,and provide reference for clinical diagnosis and treatment.Methods A total of 114 patients with IWSI admitted to Cangzhou Hospital of Integrated Chinese and Western Medicine,He-bei Province from January 2022 to May 2023 were selected.According to the infarct area shown by head magnetic resonance imaging(MRI),the 18F-FDG PET/CT quantitative parameters[standard uptake value(SUV)]of IWSI patients with different in-farct area were compared to evaluate cognitive dysfunction,and the 18F-FDG PET/CT quantitative parameters of IWSI patients with different degrees of cognitive dysfunction were compared.The prognosis was assessed by the modified Rankin Scale(mRS)for 1 month,and was divided into good prognosis group(75 patients)and poor prognosis group(39 patients).The predictive value of 18F-FDG PET/CT quantitative parameters in IWSI patients was analyzed.Results SUV in frontal,parietal,occipital,temporal and cerebellar areas in the small infarct group were higher than those in medium and large infarct groups,and SUV in all brain areas in the medium infarct group were higher than those in the large infarct group(P<0.05).Frontal SUV,parietal SUV,occipital SUV,temporal SUV and cerebellar SUV in no cognitive impairment group were all higher than those in the mild cognitive impairment group>those in the moderate cognitive impairment group>those in the severe cognitive impairment group(P<0.05).Frontal SUV,parietal SUV,occipital SUV,temporal SUV and cerebellar SUV were negatively correlated with infarct area and cognitive dysfunction in IWSI patients(P<0.05).The SUV in frontal lobe,parietal lobe,occipital lobe,temporal lobe and cerebellar lobe of IWSI patients with good prognosis were higher than those in poor prognosis group(P<0.05).The receiv-er operating characteristic curve of 18F-FDG PET/CT quantitative parameters predicted the prognosis of IWSI patients,and the results showed that area under the curve of the combined prediction of each brain region was the largest,0.910(P<0.05).Conclusion Infarct area and cognitive dysfunction of IWSI are closely related to the quantitative parameters of 18F-FDG PET/CT.The combination of SUV in different brain regions has high predictive value for IWSI prognosis,and can be used as an ef-fective indicator of IWSI infarct area,cognitive dysfunction and poor short-term prognosis.
Keywords：Internal watershed cerebral infarction18F-FDG PET/CTInfarct areaCognitive dysfunctionStandardized take-up valuesReceiver operating characteristic curve
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 85-90 )