The Relationship between Inflammation Burden Index and Ventilator-Associated Pneumonia in Stroke Patients with Mechanical Ventilation

LIU Wenshuai; WEI Jingjing; FAN Shengqiang; MENG Cuiyu; PANG Guozhong; GUO Hui

doi:10.3639/j.issn.2095-3097.2025.05.011

Abstract：Objective To explore the relationship between inflammation burden index(IBI)and the occurrence of ventilator-associated pneumonia(VAP)in stroke patients with mechanical ventilation.Methods A total of 120 stroke pa-tients with mechanical ventilation from February 2022 to February 2024 were selected.According to the occurrence of VAP,the patients were divided into the VAP group(n=29)and the non-VAP group(n=91).C-reactive protein(CRP),neutrophil,and lymphocyte count levels were detected,and the neutrophil-to-lymphocyte ratio(NLR)and IBI were calculated.The predictive value of IBI for VAP in stroke patients with mechanical ventilation was evaluated by the ROC curve.The influencing factors of VAP in stroke patients with mechanical ventilation were explored by multivariate logistic regression.Results CRP,neutrophil,NLR,and IBI in the VAP group were higher than those in the non-VAP group(P<0.05),while lymphocyte count was lower than those in the non-VAP group(P<0.05).The area under the curve(AUC)(95％CI)of IBI for predicting VAP in stroke patients with mechanical ventilation was 0.912(0.864-0.957),which was significantly higher than that of CRP and NLR alone[0.762(0.716-0.814)and 0.854(0.804-0.905),respectively](Z=9.855,8.976,P<0.001).Multivariate analysis showed that high APACHE Ⅱ score(OR=4.141,95％CI:1.861-9.214),elevated CRP(OR=2.442,95％CI:1.511-3.948),and elevated IBI(OR=3.811,95％CI:2.088-6.957)were independent risk factors for VAP in stroke patients with mechanical ventilation(P<0.05);Elevated GCS score(OR=0.485,95％CI:0.303-0.776)was an independent protective factor for VAP in stroke patients with mechanical ventilation(P<0.05).Conclusion Elevated IBI is associated with the occurrence of VAP in stroke patients with mechanical ventilation,and IBI has a high predictive value for VAP in these patients.