The Relationship between Serum Nrf2 and HO-1 Levels and the Therapeutic Effect of Targeted Therapy in Advanced Non-Small Cell Lung Cancer Patients
LI Lina
ZHOU Jing
WANG Yuzhen
JIAO Mi
CHANG Linhan
DUAN Lian
Abstract：Objective To explore the association between serum levels of nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase 1(HO-1)in patients with advanced non-small cell lung cancer(NSCLC)and their predictive value in predicting the efficacy of targeted therapy.Methods A retrospective analysis was performed on 102 patients with advanced NSCLC who received targeted therapy at Shaanxi Provincial Cancer Hospital from May 2020 to June 2024.Based on treatment response,patients were divided into an effective group(n=56)and an ineffective group(n=46).Serum Nrf2 and HO-1 levels were measured by enzyme-linked immunosorbent assay(ELISA),and differences between pre-and post-treatment levels were analyzed.The predictive value of serum Nrf2 and HO-1 for the therapeutic efficacy was assessed using receiver operating char-acteristic(ROC)curve analysis.Multivariate logistic regression was employed to identify independent factors influencing target-ed therapy outcomes.Results Post-treatment serum Nrf2 and HO-1 levels declined in both groups,but remained significantly higher in the ineffective group compared to the effective group(P＜0.05).ROC analysis showed that the area under the cruve(AUC)values of 0.804(95％CI:0.752-0.854)for Nrf2 and 0.755(95％CI:0.706-0.809)for HO-1 in predicting therapeutic efficacy,with a combined AUC of 0.902(95％CI:0.851-0.954).The effective group exhibited lower proportions of smoking history,stageⅣ pathology,and moderate-to—high tumor differentiation,as well as reduced levels of cancer antigen 123 and carcinoembry-onic antigen(P＜0.05).Multivariate analysis identified stage Ⅳ pathology(OR=2.910,95％CI:1.120-7.557),low differentiation(OR=1.701,95％CI:1.127-2.567),cancer antigen 123(OR=1.002,95％CI:1.008-1.036),Nrf2(OR=5.186,95％CI:1.775-15.152),and HO-1(OR=3.225,95％CI:1.615-6.442)as independent risk factors(P＜0.05).Conclusion Serum Nrf2 and HO-1 levels are significantly associated with targeted therapy efficacy in advanced NSCLC and may serve as predictive bio-markers.Combined assessment of both markers demonstrates superior predictive performance.
Keywords：Nuclear factor erythroid 2-related factor 2Heme oxygenase 1Advanced non-small cell lung cancerTar-geted therapy
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 42-46 )