Application Value of Esketamine Patient-Controlled Intravenous Analgesia in Postoperative Analgesia of Patients with Thoracoscopic Surgery
LIU Tong
LIN Weiwei
CHEN Dongwen
CHEN Benzhen
GAO Hongguang
JIANG Rongrong
LI Junxiang
Abstract：Objective To investigate the effects of esketamine combined with patient-controlled intravenous analgesia(PCIA)on postoperative pain and recovery in patients undergoing video-assisted thoracoscopic lobectomy(VATS).Methods A total of 74 patients who underwent VATS lobectomy between January 2023 and November 2024 were enrolled and randomly assigned via sealed-envelope method to either the esketamine group(n=37)or the control group(n=37).The esketamine group received PCIA with esketamine added to the regimen,while the control group received standard PCIA.Postoperative pain[as-sessed by the Numerical Rating Scale(NRS)],chronic post-surgical pain(CPSP),perioperative indicators,postoperative fatigue(ICFS-10),quality of recovery(QoR-15)and incidence rates of adverse events were compared between the two groups of patients..Results There was no statistical significance in the NRS score in the resting state NRS scores between groups after surgery(P>0.05).On the 2nd day after surgery,the esketamine group exhibited lower NRS scores during movement.(P<0.05),and lower CPSP scores compared to the control group(P<0.05).The esketamine group also required less sufentanil,fewer PCIA compres-sions,and had a shorter time to first ambulation(P<0.05).At different time points after surgery,the esketamine group showed lower ICFS-10 scores and higher QoR-15 scores than the control group(P<0.05).Additionally,the incidence of adverse events was significantly lower in the esketamine group(P<0.05).Conclusion Esketamine combined with PCIA effectively alleviates movement-associated pain after VATS,reduces the risk of CPSP,decreases opioid consumption,and enhances early recovery by improving postoperative fatigue and overall recovery quality,with a favorable safety profile.
Keywords：LobectomyThoracoscopicPatient-controlled intravenous analgesiaEsketaminePostoperative analgesic effect
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 161-164 )