Expression Levels of HDAC1 and FRS2 in Endometrial Carcinoma and Their Prognostic Significance
LUO Li
YANG Xu
HAN Jianxiong
WU Hongwei
LUO Daxian
Abstract：Objective To explore the expression levels of histone deacetylase 1(HDAC1)and fibroblast growth factor re-ceptor substrate 2(FRS2)in endometrial carcinoma and their prognostic significance.Methods A total of 201 endometrial cancer patients admitted to our hospital from January 2018 to December 2021 were included.Cancer tissue specimens were designated as the endometrial carcinoma group(n=201)and adjacent normal tissue specimens were designated as the paracancerous group(n=201).The expressions of HDAC1 and FRS2 in tissues were detected by immunohistochemistry.The expression levels of HDAC1 and FRS2 in patients with different clinicopathological characteristics were compared,and the prognostic factors were analyzed using multivariate Cox regression.Results The positive rates of HDAC1 and FRS2 in endometrial carcinoma group(73.13%、69.65%)were higher than those in paracancerous group(33.83%、38.32%)(P<0.05).Patients with G3 histological grade,FIGO stage Ⅲ,lymph node metastasis,or myometrial invasion>1/2 exhibited higher HDAC1 and FRS2 positivity compared to those with G1+G2 histological grade,FIGO stageⅠ+Ⅱ,no lymph node metastasis,or myometrial invasion<1/2(P<0.05).Among the 201 patients,162 cases survived,yielding an overall survival rate of 80.60%(162/201).The 3-year overall survival rate was high-er in HDAC1-negative and FRS2-negative patients than in HDAC1-positive and FRS2-positive patients(P<0.05).Multivariate Cox regression analysis showed that histological grade G3(HR=2.401,95%CI:1.205-4.787),FIGO stage Ⅲ(HR=2.519,95%CI:1.447-4.387),lymph node metastasis(HR=2.858,95%CI:1.436-5.686),muscle infiltration>1/2(HR=2.570,95%CI:1.328-4.975),HDAC1 positive(HR=3.086,95%CI:1.731-5.502),FRS2 positive(HR=3.892,95%CI:1.999-7.579)were the prognostic factors of cases with endometrial carcinoma(P<0.05).Conclusion High expression of HDAC1 and FRS2 in endometrial carci-noma is associated with poor prognosis.Additionally,histological grade G3,FIGO stageⅢ,lymph node metastasis,and muscular infiltration>1/2 are adverse prognostic factors.
Keywords：Endometrial carcinomaHistone deacetylase 1Fibroblast growth factor receptor substrate 2Prognosis
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 83-88 )