The Value of Lmr,Eos and Ldh Combined Detection in Differential Diagnosis of Benign and Malignant Pleuroperitoneal Effusion
WEN Ke
WANG Qiong
JIN Defu
LI Chang
JI Jinling
Abstract：Objective To investigate the value of combined determination of lymphocyte-to-monocyte ratio(LMR),eosinophilic granulocyte(EOS)and lactate dehydrogenase(LDH)in the differential diagnosis of benign and malignant pleuro-peritoneal effusions.Methods A total of 252 patients with pleuroperitoneal effusions admitted to our hospital from October 2021 to September 2023 were selected as the subjects,123 patients with benign lesions confirmed by surgical pathology were selected as the benign group,and 129 patients with cancer were selected as the malignant group by case-control study.A fully automated blood cell analyzer was used to detect lymphocytes,monocytes,and EOS in pleural or peritoneal fluid,with LMR calculated.A biochemical analyzer to detect LDH was used in pleural and peritoneal fluid.The diagnostic value of LMR,EOS and LDH in benign and malignant pleuroperitoneal effusion were evaluated by receiver operating characteristic(ROC)curves.Results The LMR,EOS and LDH levels in the benign group were lower than those in the malignant group(P<0.05).The AUCs of LMR,EOS and LDH in the diagnosis of benign and malignant pleuroperitoneal effusions were 0.814,0.753 and 0.619,re-spectively,and the AUC of the combined diagnosis was 0.938.The specificity of pleural fluid LMR in the diagnosis of malignant pleural fluid was the highest(0.659),followed by EOS and LDH(0.618 and 0.577,respectively).LDH had the highest sensitivity in the diagnosis of malignant pleuroperitoneal effusion(0.860),followed by EOS and LMR(0.760 and 0.744,respectively).The diagnostic specificity and sensitivity of the three indexes combined can reach 0.886 and 0.915.Conclusion The combined detection of LMR,EOS and LDH in pleural and abdominal fluid has high clinical value for differential diagnosis of benign and malignant pleural and abdominal effusions.
Keywords：lymphocyte-monocyte ratioEosinophilsLactate dehydrogenaseMalignant pleuroceliac effusion
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 56-60 )