Prognostic Value of Serum LRP6,PTRF on Fracture Healing in Cases with Tibial Fracture after Operation
WANG Chen
TIAN Biao
XU Hexuan
ZHAO Yafei
ZHAO Jitang
Abstract：Objective To investigate the predictive value of serum levels of low density lipoprotein receptor-associated protein 6(LRP6),polymerase 1 and transcription release factor(PTRF)on fracture healing in patients with tibial fracture(TF)after surgery.Methods 117 cases with TF from March 2021 to February 2024 were selected.The patients were followed up for 4 months and divided into the normal healing group(n=96)and the delayed healing group(n=21).Serum LRP6 and PTRF levels were compared between the two groups.The predictive value of serum LRP6 and PTRF for fracture healing in patients with TF was evaluated by ROC.The influencing factors of postoperative fracture healing in TF patients were explored using multivariate Logistic regression.Results The serum levels of LRP6 and PTRF in the delayed healing group were lower than those in the normal healing group(P<0.05).The area under the curve(AUC)(95%CI)of serum LRP6,PTRF and their combination in pre-dicting postoperative fracture healing in TF patients was 0.872(0.802-0.924),0.745(0.693-0.797)and 0.903(0.851-0.955),respectively.The delayed healing group had higher proportions of age,diabetes history,open fracture,complete weight-bearing time≥3 months,postoperative local infection and postoperative osteofascial compartment syndrome compared to the normal healing group(P<0.05).Multivariate analysis showed that.diabetes history(OR=2.115,95%CI:1.437-3.112),postoperative lo-cal infection(OR=2.380,95%CI:1.568-3.613),postoperative osteofascial compartment syndrome(OR=2.529,95%CI:1.669-3.833),LRP6<17.26 ng/mL(OR=0.300,95%CI:0.189-0.476),and PTRF<35.52 ng/L(OR=0.406,95%CI:0.270-0.610)were independent risk factors for delayed fracture healing(P<0.05).Conclusion Serum LRP6 and PTRF have predictive value for postoperative fracture healing in TF patients,with higher predictive power when combined.
Keywords：Tibial fractureFracture healingLow density lipoprotein receptor-associated protein 6Polymerase 1 and transcription release factor
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 45-49 )