Retrospective Analysis of the Efficacy of Wuling Capsules Combined with Agomelatine in the Treatment of Depression Complicated with Insomnia after Ischemic Stroke
WU Hao
WU Dan
LIU Zhou
JIN Congli
HUANG Chunxia
LUO Xudong
HUANG Xiaojun
Abstract：Objective To retrospectively analyze the clinical efficacy of Wuling Capsules combined with agomelatine in the treatment of depression complicated with insomnia after ischemic stroke.Methods A total of 168 patients with depression complicated with insomnia after ischemic stroke who were hospitalized in the Affiliated Hospital of Guangdong Medical University from January 2021 to June 2024 were collected as the research subjects.They were divided into two groups according to the treatment method:patient in the control group(84 cases)received agomelatine alone,and those in the experimental group(84 cases)received a combination of Wuling Capsules and agomelatine.The Hamilton Depression Rating Scale(HAMD)scores,Pittsburgh Sleep Index(PSQI),neurotransmitter indicators before and after treatment,clinical efficacy and incidence of adverse reactions were compared.Results After treatment,the experimental group showed significant improvement in mood and sleep quality compared to the control group(P＜0.05).The improvement in neurotransmitter levels was also better than that of the control group(P＜0.05),and the total clinical effective rate was significantly higher than that of the control group(P＜0.05).There was no significant increase in the incidence of adverse reactions(P＞0.05).Conclusion The combination of Wuling Capsules and agomelatine can effectively improve depression complicated with insomnia after ischemic stroke,with good safety and clinical promotion value.
Keywords：Ischemic strokeDepressionInsomniaWuling capsulesAgomelatine
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 237-240,261 )