Comparison of Clinical Effects of Isophane Protamine Recombinant Human Insulin Mixture Injection(40/60)versus Acarbose in Treating Type 2 Diabetes Mellitus
DIAO Weiwei
LI Yu
ZHANG Hongli
Abstract：Objective To explore the clinical effect of isophane protamine recombinant human insulin mixture injection(40/60)versus acarbose in treating type 2 diabetes mellitus(T2DM).Methods A total of 80 T2DM patients treated in the Suixi County People's Hospital from January 2021 to December 2024 were selected.They were randomly divided into the control group(acarbose)and observation group(isophane protamine recombinant human insulin mixture injection)using a random number table,with 40 cases per group.The treatment period was 3 months.The treatment efficacy,blood glucose,blood lipids,inflammatory factors,score of the quality of life,and safety during treatment were compared between the two groups.Results The treatment efficacy was significantly higher in the observation group than that of the control group(P＜0.05).After treatment,patients in the observation group had significantly lower fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PBG),glycosylatedhemoglobin(HbAlc),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG),and the Diabetic Mellitus Quality of Life Scale(DMQLS)score,but significantly higher high-density lipoprotein cholesterol(HDL-C)than those of the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Both isophane protamine recombinant human insulin mixture injection(40/60)and acarbose can improve blood glucose and lipid metabolism,inhibit the production of inflammatory factors,and improve the quality of life of T2DM patients.Compared to acarbose,the comprehensive efficacy of isophane protamine recombinant human insulin mixture injection(40/60)is greater.
Keywords：Type 2 diabetes mellitusIsophane protamine recombinant human insulin mixture injection(40/60)AcarboseEfficacy
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 218-222 )