Predictive Values of CT Features,iNOS,HMGB1 and MIP1α in Depression at Post-acute Cerebral Infarction
WEI Wei
WANG Jing
CUI Wei
ZHANG Jitao
WANG Siman
LI Congzhi
SHI Fuping
Abstract：Objective To analyze the predictive values of computed tomography(CT)features,inducible nitric oxide synthase(iNOS),high mobility group protein B1(HMGB1)and macrophage inflammatory protein 1α(MIP1α)in depression at post-acute cerebral infarction(ACI).Methods The clinical data of 121 ACI patients admitted to the Affiliated Hospital of Hebei University from May 2021 to September 2024 were retrospectively analyzed.All patients received intravenous thrombolytic therapy.After 1 month of treatment,patients were divided into the depression group(n=35)and non-depression group(n=86)according to the presence or absence of depression.The clinical data,CT features and serum levels of iNOS,HMGB1 and MIP1α were compared between the two groups.The influencing factors for depression at post-ACI was analyzed.The predictive values of CT features,serum iNOS,HMGB1,and MIP1α,and their combination in the occurrence of depression at post-ACI were analyzed.Results There were no significant differences in clinical data between the two groups(P＞0.05).The proportion of left hemisphere lesions,anterior circulation lesions,small-sized lesions,temporal and frontal lesions,single lesions,and CT values in the left temporal lobe,left frontal lobe and right frontal lobe in the depression group were significantly higher than those of the non-depression group(P＜0.05).There was no significance in the CT value in the right temporal lobe between the two groups(P＞0.05).Serum levels of iNOS,HMGB1 and MIP1α in the depression group were significantly higher than those of the non-depression group(P＜0.05).Lesions in the left hemisphere(OR=4.674,95％CI:2.055-10.632),lesions in the anterior circulation area(OR=3.959,95％CI:1.740-9.006),small-sized lesions(OR=3.384,95％CI:1.488-7.697),single lesions(OR=3.684,95％CI:1.619-8.380),iNOS(OR=3.040,95％CI:1.337-6.916),HMGB1(OR=2.740,95％CI:1.205-6.233)and MIP1α(OR=3.991,95％CI:1.754-9.078)were independent risk factors for depression at post-ACI(P＜0.05).The area under the curve(AUC)of CT features,serum iNOS,HMGB1,MIP1α levels and their combination in predicting depression at post-ACI was 0.815,0.802,0.843,0.799,0.925,respectively(P＜0.05).AUC of their combination was significantly higher than the single indicator(P＜0.05).Conclusion CT features,serum iNOS,HMGB1 and MIP1αlevels have important value in predicting depression at post-ACI,especially their combination.
Keywords：Cerebral infarctionDepressionSpiral cone-beam computed tomographyInducible nitric oxide synthaseHigh mobility group protein B1Macrophage inflammatory protein 1αLogistic modelROC curve
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 108-112,276 )