Expression of PFTK1 Protein in Colon Cancer Tissues and Relationship with Clinicopathology and Prognosis

ZHENG Guangmao; HU Shaolong; CHEN Meiling; GUO Yamin; FENG Yanpin; LI Jianjun; GAO Xiufang

doi:10.3639/i.issn.2095-3097.2025.02.011

Abstract：Objective To analyze the expression of PFTAIRE protein kinase 1(PFTK1)in colon cancer tissues and the relationship with clinicopathology and prognosis.Methods A total of 296 patients with colon cancer who underwent surgical treatment in Zhangjiakou First Hospital from March 2017 to September 2021.Samples of surgically removed cancer tissues(cancer tissue group)and adjacent tissues 2cm away from the edge of the cancer focus(adjacent tissue group)were collected and the positive expression of PFTK1 was compared in patients with different clinicopathological characteristics of colon cancer.The 5-year prognosis survival was evaluated for patients with PFTK1 positive and negative expression in colon cancer tissues.Results The positive expression rate of PFTK1 was significantly higher in colon cancer tissues than in adjacent tissues(P＜0.05).There were statistical differences in the positive expression rate and expression intensity of PFTK1 in colon cancer patients with different invasion depths,lymph node metastasis,and distant metastasis(all P＜0.05).Spearman rank correlation analysis showed that the expression intensity of PFTK1 in colon cancer tissues was significantly positively correlated with invasion depth,lymph node metastasis,and distant metastasis(r=0.756,0.409,0.554,P＜0.05).With death or 5 years after surgery as the follow-up endpoint,66 cases reached the follow-up endpoint,including 31 cases with PFTK1 positive expression and 35 cases with negative expression in colon cancer tissues.The 5-year survival rate and survival time of patients with PFTK1 positive expression were lower or shorter than those of patients with negative expression(P＜0.05).Conclusion The expression intensity of PFTK1 is related to the malignant biological behaviors of invasion and metastasis in colon cancer tissues and may also affect the prognosis and survival time of colon cancer patients.