Bronchial Arterial Infusion Chemotherapy Combined with Sintilimab Followed by Radical Radiotherapy in the Treatment of Large Stage Ⅲ Squamous Non-small Cell Lung Cancer:a Single-center,Single-arm Study
CHEN Xiaochun
LIN Chuan
BI Hongqin
WANG Changping
LI Qian
DENG Wanbing
HU Chuanfei
WANG Siyu
LIU Hongling
YUAN Zhiping
Abstract：Objective To explore the efficacy and safety of bronchial arterial infusion(BAI)chemotherapy combined with immune checkpoint inhibitors followed by radical radiotherapy in the treatment of large mass stage Ⅲ squamous non-small cell lung cancer.Methods Sixteen patients with inoperable stage Ⅲ squamous non-small cell lung cancer who were treated in the First People's Hospital of Yibin from August 2021 to December 2023 were included and underwent BAI combined with immunotherapy,followed by radical radiotherapy.Results Among the 16 patients,the 1-year and 2-year progression-free survival(PFS)rates were 87.5%(14 case)and 46.41%(8 case),respectively,and the median progression-free survival(mPFS)was 24.03 months.The 1-year and 2-year overall survival(OS)rates were 93.75%(15 case)and 66.20%(11 case)respectively,and the median overall survival(mOS)was not reached.The objective response rate(ORR)after BAI chemotherapy combined with immunotherapy was 56.25%(9/16),and after radical radiotherapy it was 75.00%(12/16).In terms of safety,the total incidence rate of adverse events was 93.75%,including 43.75%(7/16)pneumonia,1 case(6.25%)in grade 3(G3),and 1 case(6.25%)in G5.Conclusion BAI combined with immunotherapy and sequential radical radiotherapy have certain safety and efficacy in patients with stage Ⅲ lung squamous cell carcinoma with large tumor masses.However,given the limited sample size of the included studies and the heterogeneity of the treatments used,the findings need further validation in larger clinical trials.
Keywords：Cancernon-small cell lungTumorsquamous cellsChemotherapyLocal perfusionImmune checkpoint inhibitorsRadiation therapyComparative study of curative effect
Publication Date：2025-01-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 105-111 )