Combined Therapy of Bupleurum Plus Longgu Muli Decoction with Metoprolol for Coronary Heart Disease Complicated with Tachyarrhythmias

LI Xuemei; ZHANG Pengtao; ZHANG Jianhui

doi:10.3639/j.issn.2095-3097.2024.11.044

Abstract：Objective To explore the clinical efficacy of Bupleurum plus Longgu Muli Decoction combined with Me-toprolol in treating coronary heart disease complicated with tachyarrhythmias.Methods A retrospective analysis was con-ducted on 100 patients with CHD and arrhythmia admitted to our hospital from January 2022 to January 2024.The patients were divided into two groups based on the treatment method:the control group(52 cases)received metoprolol alone,while the ob-servation group(48 cases)received Bupleurum plus Longgu Muli Decoction with modifications in combination with metoprolol.Clinical efficacy,adverse reactions,Traditional Chinese Medicine(TCM)symptom scores,cardiac function,Holter electrocar-diography,and hemorheological parameters were compared between the two groups.Results The effective rate in the obser-vation group reached 94.2%,notably surpassing the 79.1%in the control group(P<0.05).After treatment,both groups showed a reduction in TCM symptom scores,with the observation group scoring significantly lower than the control group(P<0.05).The observation group demonstrated a significant improvement in left ventricular ejection fraction(LVEF)and cardiac output(CO)compared to the control group,along with a significant reduction in left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)(P<0.05).No notable difference was found in the rate of adverse reactions between the two groups(P>0.05).Conclusion The combination of Bupleurum plus Longgu Muli Decoction with metoprolol in the treatment of CHD complicated by rapid arrhythmia can enhance clinical efficacy,alleviate clinical symptoms,improve cardiac function,with satisfied safety.