Effect of Folic Acid Administration Period,Dose and Duration on the Pathogenesis of Gestational Diabetes Mellitus and Delivery Outcome
XU Linying
SUN Jing
WU Hongye
TONG Xiaofang
LI Yanfeng
Abstract：Objective To study the role of folic acid administration period,dosage and duration in the pathogenesis of gestational diabetes mellitus(GDM)and its impact on the delivery outcome.Methods A retrospective analysis was conducted to select 120 GDM patients who were admitted to our obstetrics and gynecology department from February 2019 to February 2022 for the study,and 120 healthy pregnant women(120 cases)in the same period as the control group.The folic acid consumption(duration,dosage and duration)of pregnant women was investigated,and the pregnancy outcome was counted.The relationship between folic acid use and the risk of GDM was analyzed,and the impact of folic acid use on the delivery outcome was analyzed by logistic regression.Results Among 240 pregnant women,122(50.83％)took folic acid at 400 pg/day,86(35.83％)took folic acid at 800 pg/day,10(4.17％)took folic acid at 1 400 pg/day,and 26(10.83％)took folic acid for less than 4 weeks(excluding 0 weeks);192 pregnant women(80.00％)took folic acid for more than 4 weeks.45 cases(18.75％)started taking folic acid before pregnancy and 173 cases(72.08％)started taking folic acid during pregnancy.Folic acid dose was an independent influencing factor for the development of GDM(P＜0.05),and folic acid dose＞400 pg/day could increase the risk of GDM.The main adverse pregnancy outcomes were placenta previa,postpartum hemorrhage,fetal distress,malformation and premature delivery.The incidence of adverse pregnancy outcomes in GDM group(18.33％vs 8.33％)was higher than that in control group(P＜0.05).The proportion of folic acid dose 1 400 pg/day and duration＜4 weeks(including 0 weeks)in pregnant women with poor pregnancy outcome was higher than that in pregnant women with good pregnancy outcome(P＜0.05).Dose and duration of folic acid were independent influencing factors for the occurrence of GDM(P＜0.05),and dose＞400 pg/day and duration＜4 weeks could increase the risk of GDM.Conclusion High dose folic acid can increase the risk of GDM,and short-term or high dose folic acid can increase the risk of adverse pregnancy outcomes.Therefore,it is necessary to continue to take appropriate folic acid during pregnancy.
Keywords：Folic acidGestational diabetes mellitusPregnancy outcomeInfluencing factors
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1795-1799 )