Clinical Efficacy of Intracranial Injection of Urokinase in the Treatment of Acute Cerebral Hemorrhage and Its Impact on Helper T Cell Factors and Coagulation Function
QIAN Xuanchen
WANG Yong
BAO Hanmo
WU Yuxuan
Abstract：Objective To observe the clinical efficacy of intracranial injection of urokinase in the treatment of acute cerebral hemorrhage and its impacts on helper T(Th)cell factors,coagulation function,inflammatory factors,neurological function and vital signs.Methods A retrospective analysis was conducted.Eighty patients with acute cerebral hemorrhage admitted to the Affiliated Hospital of Xuzhou Medical University from March 2021 to April 2024 were included.According to the treatment methods,they were divided into the observation group(40 cases,receiving intracranial injection of urokinase after cranial drilling and drainage combined with conventional treatment)and the control group(40 cases,receiving conventional treatment).The changes in hematoma volume,Th cell factors,coagulation function,inflammatory factors,neurological function and vital signs were compared between the two groups.Results On the 3rd,7th and 14th days after treatment,the hematoma volumes of both the observation group and the control group gradually decreased(P＜0.05),and that of the observation group was smaller than that of the control group(P＜0.05).On the 14th day after treatment,the interferon-γ(IFN-γ)level decreased(P＜0.05)and the interleukin-4(IL-4)level increased(P＜0.05)in both groups,and the IFN-γ level in the observation group was lower than that in the control group(P＜0.05),while the IL-4 level was higher than that in the control group(P＜0.05).On the 3rd,7th and 14th days after treatment,there were no significant changes in prothrombin time(PT)and activated partial thromboplastin time(APTT)in both groups(P＞0.05).After treatment,the fibrinogen(FIB)and D-dimer(D-D)levels of both groups gradually decreased(P＜0.05),and on the 7th and 14th days after treatment,the FIB and D-D levels in the observation group were lower than those in the control group(P＜0.05).On the 3rd,7th and 14th days after treatment,the C-reactive protein(CRP)and interleukin-1β(IL-1β)levels of both groups were significantly lower than those before treatment(P＜0.05),and the CRP and IL-1β levels in the observation group were lower than those in the control group(P＜0.05).On the 7th and 14th days after treatment,the National Institutes of Health Stroke Scale(NIHSS)scores of both the observation group and the control group were lower than those before treatment(P＜0.05),and those of the observation group were lower than those of the control group(P＜0.05).After treatment,all vital sign indicators of the two groups of patients were improved compared with those before treatment(P＜0.05),and on the 7th,14th days and at discharge,the improvement of all vital sign indicators in the observation group was better than that in the control group(P＜0.05).Conclusion The combination of intracranial injection of urokinase and conventional treatment for acute cerebral hemorrhage has remarkable efficacy.It can effectively remove hematoma,regulate the balance of Th cell factors,improve the inflammatory response and coagulation function,promote the recovery of neurological function,and stabilize the vital signs.
Keywords：Cerebral hemorrhageUrokinaseIntracranial injectionT cell factorCoagulation function
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1784-1790 )