The Correlation between PTTG1 and Survival Prognosis in Patients with Renal Clear Cell Carcinoma
YU Yaoqi
NIU Jirui
YU Yin
XING Zhaohui
WANG Qi
SUN Jiaxin
Abstract：Objective To explore the correlation between Pituitary Tumor Transforming Gene 1(PTTG1)and the survival prognosis of patients with renal clear cell carcinoma.Methods A retrospective analysis was conducted on 79 patients with renal clear cell carcinoma who underwent surgical treatment in our hospital from January 2017 to January 2021.After a 3-year follow-up,patients were divided into a survival group and a death group based on disease-specific mortality outcomes.The expression of PTTG1 mRNA in the two groups was compared,and the survival prognosis of patients with different PTTG1 mRNA expressions was analyzed.Results Among the 79 patients with renal clear cell carcinoma,58 exhibited positive expression of PTTG1,while 21 were negative.The expression level of PTTG1 mRNA in cancer tissues was higher than that in adjacent normal tissues(P＜0.05).At the end of the follow-up,there were 27 cases of disease-specific mortality,with a disease-specific mortality rate of 34.18％.The proportion of Fuhrman grades Ⅲ-Ⅳ,TNM stages Ⅲ-Ⅳ,and elevated PTTG1 mRNA levels was higher in the death group compared to the survival group(P＜0.05).Fuhrman grade,TNM stage,and PTTG1 mRNA were identified as risk factors for prognosis and mortality in patients with renal clear cell carcinoma(P＜0.05).The survival curve of patients with high expression of PTTG1 mRNA was lower than that of patients with low expression(P＜0.05).Conclusion High expression of PTTG1 in renal clear cell carcinoma is associated with patients'disease-specific mortality prognosis.
Keywords：Renal clear cell carcinomaPituitary tumor transformation gene 1CorrelationSurvivorship
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1708-1711,1717 )