Mechanical Valve Replacement for Improving Valve Function,Cardiac Function,and Myocardial Protection in Patients with Valvular Heart Disease
ZHENG Xiong
WANG Xiaofang
ZHANG Zhen
YANG Bo
LIU Lei
Abstract：Objective To investigate the effects of mechanical valve replacement on valve function,cardiac function,and myocardial protection in patients with valvular heart disease.Methods This retrospective study analyzed 103 patients with valvular heart disease treated at Fuyang People's Hospital from December 2020 to June 2023 All patients underwent mechanical valve replacement.The sinus rhythm restoration rate was analyzed of patients with atrial fibrillation at the end of surgery and 3 months postoperatively.Levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),homocysteine,cardiac troponin Ⅰ(cTnⅠ),creatine kinase-MB(CK-MB),and N-terminal pro-B-type natriuretic peptide(NT-proBNP)were compared preoperatively and 3 days postoperatively.Left atrial diameter(LAD),left ventricular end-diastolic diameter(LVEDD),and ejection fraction(EF)were evaluated preoperatively and 1 year postoperatively.Postoperative complications were recorded.Results The sinus rhythm restoration rate of 75 patients with atrial fibrillation at 3 months postoperatively(24.00％,18/75)was significantly higher than that at the end of surgery(10.67％,8/75)(P＜0.05).Three days postoperatively,IL-6,TNF-α,homocysteine,cTnⅠ,CK-MB,and NT-proBNP levels were significantly lower than their preoperative levels(P＜0.05).At 1 year postoperatively,LAD and LVEDD were significantly reduced compared to preoperative levels(P＜0.05),while EF was significantly increased(P＜0.05).Postoperative complications included 3 cases of gingival bleeding,1 case of cerebral hemorrhage,2 cases of subcutaneous mucosal bleeding,and 1 case of cerebral infarction,with an overall incidence of 6.80％(7/103).Symptoms were alleviated after appropriate treatment.Conclusion Mechanical valve replacement provides significant therapeutic benefits for patients with valvular heart disease,including improving sinus rhythm restoration rates,reducing IL-6,TNF-α,and homocysteine levels,enhancing cardiac function,and strengthening myocardial protection.The procedure has a low complication rate and high safety,making it suitable for clinical application.
Keywords：Mechanical valve replacementHeart valve prosthesisCardiac valvular diseaseValve functionCardiac functionMyocardial protection
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1681-1684 )