Exploring the Efficacy and Heart Rate Variability of Ivabradine Combined with Sacubitril Valsartan in Chronic Heart Failure Treatment
Ni Yang
Luo Huimin
Abstract：Objective To explore the efficacy and heart rate variability of ivabradine combined with sacubitril valsar-tan in the treatment of chronic heart failure.Methods A total of 180 patients with heart failure treated at Zhongnan Hospital,Wuhan University,from October 2022 to October 2023 were retrospectively analyzed.Patients were divided into a reference group(n=90,treated with sacubitril valsartan)and a study group(n=90,treated with ivabradine combined with sacubitril valsar-tan).The therapeutic effects,cardiac function indices,heart rate variability indices,and serum levels of soluble suppression of tumorigenicity 2(sST-2),soluble intercellular adhesion molecule-1(sICAM-1),and N-terminal pro-brain natriuretic peptide(NT-proBNP)were compared between the two groups.Results The effective treatment rate in the study group was signifi-cantly higher than that in the reference group(P＜0.05).The study group showed significantly improved left ventricular ejection fraction(LVEF)and reduced LVEDd compared to the reference group(P＜0.05).Heart rate variability indices and serum lev-els of sST-2,sICAM-1,and NT-proBNP were significantly reduced in the study group compared to the reference group after treatment(P＜0.05).Conclusion The combination of ivabradine and sacubitril valsartan effectively improves cardiac function indices,enhances treatment efficiency,and lowers serum sST-2,sICAM-1,and NT-proBNP levels in heart failure patients.The treatment shows significant therapeutic effects and is worthy of clinical application.
Keywords：IvabradineSacubitril valsartanHeart failureSoluble suppression of tumorigenicity2Heart rate variabilityc
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1536-1541 )